Kelleher honored by Irish America’s Healthcare and Life Sciences 50 Award.

Dr. Neil Kelleher received the Healthcare and Life Sciences award by Irish America magazine in Manhattan. Kelleher was one of fifty honorees for his work with the Proteomics Center of Excellence and the Kelleher Research Group.

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Northwestern Team Develops System for Simplifying Sample Cleanup in Top-Down Proteomics

The lab of Northwestern University researcher Neil Kelleher has developed an on-line system for clean up of top-down proteomics samples following gel eluted liquid fraction entrapment electrophoresis (GELFrEE) fractionation. The system, detailed in a paper published in May 2015 in the Journal of Proteome Research, uses asymmetrical flow field-flow fractionation (AF4) to address what is a key challenge in top-down proteomic workflows, and could make top-down approaches more widely shareable as well as improve their applicability to clinical work, Philip Compton, director of instrumentation at NorthWestern's Proteomics Center of Excellence and an author on the paper, told GenomeWeb.

Kelleher Lab featured in Feinberg News Center

Chemicals found in nature have long been known for their potential to benefit human health, directly and indirectly forming the basis for antibiotics, anti-cancer therapies and other drugs. But identifying promising bioactive compounds within vast natural resources is like slowly chipping away at a mountain range in search of gold. In a recent study published in Nature Chemical Biology, Northwestern Medicine scientists developed a method to systematically explore large data sets of bacterial molecules to identify thousands of potential drug leads in one fell swoop.

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Hear about the Top Down version of the Human Proteome Project!

The tectonic collision of biology with separation science, MS, and informatics occurred over the past 15 years and was driven by contributions from more than 100 laboratories. Like budding yeast, MS is sprouting emergent approaches for the direct profiling and MS/MS analysis of heterogeneous proteins in ever more complex mixtures. Such approaches promise to determine molecular indicators of complex diseases and deepen our understanding of dynamic regulatory mechanisms in cell biology.
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Natural Products subgroup is focused on the discovery and biosynthesis of novel natural products. Developments from this subgroup include the introduction of the PrISM platform, geared towards the identification of natural products synthesized by nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) without prior knowledge of a gene sequence. This is made possible by our ability to detect a phosphopantetheinyl (Ppant) ejection marker ion for NRPS/PKS thiolation domains. We also work in collaboratithisith groups from other universities to provide mass spectrometry analysis of novel biochemical biology.

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