Publications

280 entries « 1 of 6 »

2017

Zha, L; Y.Jiang, ; amd Wilson, M.T.Henke M R; J.X.Wang, ; N.L.Kelleher, ; E.P.Balskus,

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring. Journal Article

Nat Chem Biol, 13 (10), pp. 1063-1065, 2017.

Abstract | Links | BibTeX | Tags:

Mascarenhas, R; Le, H V; Clevenger, K D; Lehrer, H J; Ringe, D; Kelleher, N L; Silverman, R B; Liu, D

Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Journal Article

Biochemistry, 56 (37), pp. 4951-4961, 2017.

Abstract | Links | BibTeX | Tags:

Anderson, L C; DeHart, C J; Kaiser, N K; Fellers, R T; Smith, D F; Greer, J B; LeDuc, R D; Blakney, G T; Thomas, P M; Kelleher, N L; Hendrickson, C L

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry Journal Article

J Proteome Res, 16 (2), pp. 1087-1096, 2017, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Cleland, T P; DeHart, C J; Fellers, R T; VanNispen, A J; Greer, J B; LeDuc, R D; Parker, W R; Thomas, P M; Kelleher, N L; Brodbelt, J S

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer Journal Article

J Proteome Res, 16 (5), pp. 2072-2079, 2017, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Clevenger, K D; Bok, J W; Ye, R; Miley, G P; Verdan, M H; Velk, T; Chen, C; Yang, K; Robey, M T; Gao, P; Lamprecht, M; Thomas, P M; Islam, M N; Palmer, J M; Wu, C C; Keller, N P; Kelleher, N L

A scalable platform to identify fungal secondary metabolites and their gene clusters Journal Article

Nat Chem Biol, 2017, ISSN: 1552-4469 (Electronic) 1552-4450 (Linking).

Links | BibTeX | Tags:

Clevenger, K D; Mascarenhas, R; Catlin, D; Wu, R; Kelleher, N L; Drake, E J; Gulick, A M; Liu, D; Fast, W

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ Journal Article

ACS Chem Biol, 12 (3), pp. 643-647, 2017, ISSN: 1554-8937 (Electronic) 1554-8929 (Linking).

Links | BibTeX | Tags:

DeHart, C J; Fellers, R T; Fornelli, L; Kelleher, N L; Thomas, P M

Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite Journal Article

Methods Mol Biol, 1558 , pp. 381-394, 2017, ISSN: 1940-6029 (Electronic) 1064-3745 (Linking).

Links | BibTeX | Tags:

Fornelli, L; Durbin, K R; Fellers, R T; Early, B P; Greer, J B; LeDuc, R D; Compton, P D; Kelleher, N L

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer Journal Article

J Proteome Res, 16 (2), pp. 609-618, 2017, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Fornelli, L; Toby, T K; Schachner, L F; Doubleday, P F; Srzentic, K; DeHart, C J; Kelleher, N L

Top-down proteomics: Where we are, where we are going? Journal Article

J Proteomics, 2017, ISSN: 1876-7737 (Electronic) 1874-3919 (Linking).

Links | BibTeX | Tags:

Gan, R; Perez, J G; Carlson, E D; Ntai, I; Isaacs, F J; Kelleher, N L; Jewett, M C

Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins Journal Article

Biotechnol Bioeng, 114 (5), pp. 1074-1086, 2017, ISSN: 1097-0290 (Electronic) 0006-3592 (Linking).

Links | BibTeX | Tags:

Goering, A W; Li, J; McClure, R A; Thomson, R J; Jewett, M C; Kelleher, N L

In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis Journal Article

ACS Synth Biol, 6 (1), pp. 39-44, 2017, ISSN: 2161-5063 (Electronic) 2161-5063 (Linking).

Links | BibTeX | Tags:

Greer, S M; Holden, D D; Fellers, R; Kelleher, N L; Brodbelt, J S

Modulation of Protein Fragmentation Through Carbamylation of Primary Amines Journal Article

J Am Soc Mass Spectrom, 28 (8), pp. 1587-1599, 2017, ISSN: 1879-1123 (Electronic) 1044-0305 (Linking).

Links | BibTeX | Tags:

Haverland, N A; Skinner, O S; Fellers, R T; Tariq, A A; Early, B P; LeDuc, R D; Fornelli, L; Compton, P D; Kelleher, N L

Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry Journal Article

J Am Soc Mass Spectrom, 28 (6), pp. 1203-1215, 2017, ISSN: 1879-1123 (Electronic) 1044-0305 (Linking).

Links | BibTeX | Tags:

Mandacaru, S C; do Vale, L H; Vahidi, S; Xiao, Y; Skinner, O S; Ricart, C A; Kelleher, N L; de Sousa, M V; Konermann, L

Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools Journal Article

Biochemistry, 56 (11), pp. 1645-1655, 2017, ISSN: 1520-4995 (Electronic) 0006-2960 (Linking).

Links | BibTeX | Tags:

Piunti, A; Hashizume, R; Morgan, M A; Bartom, E T; Horbinski, C M; Marshall, S A; Rendleman, E J; Ma, Q; Takahashi, Y H; Woodfin, A R; Misharin, A V; Abshiru, N A; Lulla, R R; Saratsis, A M; Kelleher, N L; James, C D; Shilatifard, A

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas Journal Article

Nat Med, 23 (4), pp. 493-500, 2017, ISSN: 1546-170X (Electronic) 1078-8956 (Linking).

Links | BibTeX | Tags:

Schroeter, E R; DeHart, C J; Cleland, T P; Zheng, W; Thomas, P M; Kelleher, N L; Bern, M; Schweitzer, M H

Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein Journal Article

J Proteome Res, 16 (2), pp. 920-932, 2017, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Toby, T K; Abecassis, M M; Kim, K; Thomas, P M; Fellers, R T; LeDuc, R D; Kelleher, N L; Demetris, J; Levitsky, J

Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients Journal Article

Am J Transplant, 2017, ISSN: 1600-6143 (Electronic) 1600-6135 (Linking).

Links | BibTeX | Tags:

2016

Chen, Y; McClure, R A; Kelleher, N L

Screening for Expressed Nonribosomal Peptide Synthetases and Polyketide Synthases Using LC-MS/MS-Based Proteomics Journal Article

Methods Mol Biol, 1401 , pp. 135-47, 2016, ISSN: 1940-6029 (Electronic) 1064-3745 (Linking).

Links | BibTeX | Tags:

Durbin, K R; Fornelli, L; Fellers, R T; Doubleday, P F; Narita, M; Kelleher, N L

Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa Journal Article

J Proteome Res, 15 (3), pp. 976-82, 2016, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Goering, A W; McClure, R A; Doroghazi, J R; Albright, J C; Haverland, N A; Zhang, Y; Ju, K S; Thomson, R J; Metcalf, W W; Kelleher, N L

Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer Journal Article

ACS Cent Sci, 2 (2), pp. 99-108, 2016, ISSN: 2374-7943 (Print) 2374-7943 (Linking).

Links | BibTeX | Tags:

Gunn, B; Schneider, J; Shansab, M; Bastian, A R; Fahrbach, K; th Smith, A; Mahan, A; Karim, M; Licht, A; Zvonar, I; Tedesco, J; Anderson, M; Chapel, A; Suscovich, T; Malaspina, D; Streeck, H; Walker, B D; Kim, A; Lauer, G; Altfeld, M; Pillai, S; Szleifer, I; Kelleher, N L; Kiser, P F; Hope, T J; Alter, G

Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16 Journal Article

Mucosal Immunol, 9 (6), pp. 1549-1558, 2016, ISSN: 1935-3456 (Electronic) 1933-0219 (Linking).

Links | BibTeX | Tags:

Hattori, T; Lai, D; Dementieva, I S; Montano, S P; Kurosawa, K; Zheng, Y; Akin, L R; Swist-Rosowska, K M; Grzybowski, A T; Koide, A; Krajewski, K; Strahl, B D; Kelleher, N L; Ruthenburg, A J; Koide, S

Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation Journal Article

Proc Natl Acad Sci U S A, 113 (8), pp. 2092-7, 2016, ISSN: 1091-6490 (Electronic) 0027-8424 (Linking).

Links | BibTeX | Tags:

Henke, M T; Kelleher, N L

Modern mass spectrometry for synthetic biology and structure-based discovery of natural products Journal Article

Nat Prod Rep, 33 (8), pp. 942-50, 2016, ISSN: 1460-4752 (Electronic) 0265-0568 (Linking).

Links | BibTeX | Tags:

Henke, M T; Soukup, A A; Goering, A W; McClure, R A; Thomson, R J; Keller, N P; Kelleher, N L

New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans Journal Article

ACS Chem Biol, 11 (8), pp. 2117-23, 2016, ISSN: 1554-8937 (Electronic) 1554-8929 (Linking).

Links | BibTeX | Tags:

Kenney, G E; Goering, A W; Ross, M O; DeHart, C J; Thomas, P M; Hoffman, B M; Kelleher, N L; Rosenzweig, A C

Characterization of Methanobactin from Methylosinus sp. LW4 Journal Article

J Am Chem Soc, 138 (35), pp. 11124-7, 2016, ISSN: 1520-5126 (Electronic) 0002-7863 (Linking).

Links | BibTeX | Tags:

LaFave, L M; Beguelin, W; Koche, R; Teater, M; Spitzer, B; Chramiec, A; Papalexi, E; Keller, M D; Hricik, T; Konstantinoff, K; Micol, J B; Durham, B; Knutson, S K; Campbell, J E; Blum, G; Shi, X; Doud, E H; Krivtsov, A V; Chung, Y R; Khodos, I; de Stanchina, E; Ouerfelli, O; Adusumilli, P S; Thomas, P M; Kelleher, N L; Luo, M; Keilhack, H; Abdel-Wahab, O; Melnick, A; Armstrong, S A; Levine, R L

Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status" Journal Article

Nat Med, 22 (6), pp. 578-9, 2016, ISSN: 1546-170X (Electronic) 1078-8956 (Linking).

Links | BibTeX | Tags:

Liu, F; Koval, M; Ranganathan, S; Fanayan, S; Hancock, W S; Lundberg, E K; Beavis, R C; Lane, L; Duek, P; McQuade, L; Kelleher, N L; Baker, M S

Systems Proteomics View of the Endogenous Human Claudin Protein Family Journal Article

J Proteome Res, 15 (2), pp. 339-59, 2016, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

McClure, R A; Goering, A W; Ju, K S; Baccile, J A; Schroeder, F C; Metcalf, W W; Thomson, R J; Kelleher, N L

Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations Journal Article

ACS Chem Biol, 11 (12), pp. 3452-3460, 2016, ISSN: 1554-8937 (Electronic) 1554-8929 (Linking).

Links | BibTeX | Tags:

Melani, R D; Seckler, H S; Skinner, O S; Vale, Do L H; Catherman, A D; Havugimana, P C; de Sousa, Valle M; Domont, G B; Kelleher, N L; Compton, P D

CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis Journal Article

J Vis Exp, (108), pp. 53597, 2016, ISSN: 1940-087X (Electronic) 1940-087X (Linking).

Links | BibTeX | Tags:

Melani, R D; Skinner, O S; Fornelli, L; Domont, G B; Compton, P D; Kelleher, N L

Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics Journal Article

Mol Cell Proteomics, 15 (7), pp. 2423-34, 2016, ISSN: 1535-9484 (Electronic) 1535-9476 (Linking).

Links | BibTeX | Tags:

Moussazadeh, N; Berman, S H; Laufer, I; Gounder, M; Zheng, Y; Sommer, J; Bilsky, M H; Kelleher, N L; Brennan, C

365 Epigenetic Profiling Reveals a Unique Histone Code in Chordoma Journal Article

Neurosurgery, 63 Suppl 1 , pp. 208, 2016, ISSN: 1524-4040 (Electronic) 0148-396X (Linking).

Links | BibTeX | Tags:

Ntai, I; LeDuc, R D; Fellers, R T; Erdmann-Gilmore, P; Davies, S R; Rumsey, J; Early, B P; Thomas, P M; Li, S; Compton, P D; Ellis, M J; Ruggles, K V; Fenyo, D; Boja, E S; Rodriguez, H; Townsend, R R; Kelleher, N L

Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts Journal Article

Mol Cell Proteomics, 15 (1), pp. 45-56, 2016, ISSN: 1535-9484 (Electronic) 1535-9476 (Linking).

Links | BibTeX | Tags:

Ntai, I; Toby, T K; LeDuc, R D; Kelleher, N L

A Method for Label-Free, Differential Top-Down Proteomics Journal Article

Methods Mol Biol, 1410 , pp. 121-33, 2016, ISSN: 1940-6029 (Electronic) 1064-3745 (Linking).

Links | BibTeX | Tags:

Ong, T H; Romanova, E V; Roberts-Galbraith, R H; Yang, N; Zimmerman, T A; Collins, 3rd J J; Lee, J E; Kelleher, N L; Newmark, P A; Sweedler, J V

Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea Journal Article

J Biol Chem, 291 (15), pp. 8109-20, 2016, ISSN: 1083-351X (Electronic) 0021-9258 (Linking).

Links | BibTeX | Tags:

Savaryn, J P; Skinner, O S; Fornelli, L; Fellers, R T; Compton, P D; Terhune, S S; Abecassis, M M; Kelleher, N L

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry Journal Article

J Proteomics, 134 , pp. 76-84, 2016, ISSN: 1876-7737 (Electronic) 1874-3919 (Linking).

Links | BibTeX | Tags:

Savaryn, J P; Toby, T K; Catherman, A D; Fellers, R T; LeDuc, R D; Thomas, P M; Friedewald, J J; Salomon, D R; Abecassis, M M; Kelleher, N L

Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection Journal Article

Proteomics, 16 (14), pp. 2048-58, 2016, ISSN: 1615-9861 (Electronic) 1615-9853 (Linking).

Links | BibTeX | Tags:

Savaryn, J P; Toby, T K; Kelleher, N L

A researcher's guide to mass spectrometry-based proteomics Journal Article

Proteomics, 16 (18), pp. 2435-43, 2016, ISSN: 1615-9861 (Electronic) 1615-9853 (Linking).

Links | BibTeX | Tags:

Schroeter, E R; DeHart, C J; Schweitzer, M H; Thomas, P M; Kelleher, N L

Bone protein "extractomics": comparing the efficiency of bone protein extractions of Gallus gallus in tandem mass spectrometry, with an eye towards paleoproteomics Journal Article

PeerJ, 4 , pp. e2603, 2016, ISSN: 2167-8359 (Print).

Links | BibTeX | Tags:

Skinner, O S; Havugimana, P C; Haverland, N A; Fornelli, L; Early, B P; Greer, J B; Fellers, R T; Durbin, K R; Vale, Do L H; Melani, R D; Seckler, H S; Nelp, M T; Belov, M E; Horning, S R; Makarov, A A; LeDuc, R D; Bandarian, V; Compton, P D; Kelleher, N L

An informatic framework for decoding protein complexes by top-down mass spectrometry Journal Article

Nat Methods, 13 (3), pp. 237-40, 2016, ISSN: 1548-7105 (Electronic) 1548-7091 (Linking).

Links | BibTeX | Tags:

Skinner, O S; Schachner, L F; Kelleher, N L

The Search Engine for Multi-Proteoform Complexes: An Online Tool for the Identification and Stoichiometry Determination of Protein Complexes Journal Article

Curr Protoc Bioinformatics, 56 , pp. 13 30 1-13 30 11, 2016, ISSN: 1934-340X (Electronic) 1934-3396 (Linking).

Links | BibTeX | Tags:

Toby, T K; Fornelli, L; Kelleher, N L

Progress in Top-Down Proteomics and the Analysis of Proteoforms Journal Article

Annu Rev Anal Chem (Palo Alto Calif), 9 (1), pp. 499-519, 2016, ISSN: 1936-1335 (Electronic) 1936-1327 (Linking).

Links | BibTeX | Tags:

Zheng, Y; Fornelli, L; Compton, P D; Sharma, S; Canterbury, J; Mullen, C; Zabrouskov, V; Fellers, R T; Thomas, P M; Licht, J D; Senko, M W; Kelleher, N L

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression Journal Article

Mol Cell Proteomics, 15 (3), pp. 776-90, 2016, ISSN: 1535-9484 (Electronic) 1535-9476 (Linking).

Links | BibTeX | Tags:

Zheng, Y; Huang, X; Kelleher, N L

Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry Journal Article

Curr Opin Chem Biol, 33 , pp. 142-50, 2016, ISSN: 1879-0402 (Electronic) 1367-5931 (Linking).

Links | BibTeX | Tags:

2015

Albright, J C; Henke, M T; Soukup, A A; McClure, R A; Thomson, R J; Keller, N P; Kelleher, N L

Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation Journal Article

ACS Chem Biol, 10 (6), pp. 1535-41, 2015, ISSN: 1554-8937 (Electronic) 1554-8929 (Linking).

Links | BibTeX | Tags:

Amiram, M; Haimovich, A D; Fan, C; Wang, Y S; Aerni, H R; Ntai, I; Moonan, D W; Ma, N J; Rovner, A J; Hong, S H; Kelleher, N L; Goodman, A L; Jewett, M C; Soll, D; Rinehart, J; Isaacs, F J

Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids Journal Article

Nat Biotechnol, 33 (12), pp. 1272-1279, 2015, ISSN: 1546-1696 (Electronic) 1087-0156 (Linking).

Links | BibTeX | Tags:

Bok, J W; Ye, R; Clevenger, K D; Mead, D; Wagner, M; Krerowicz, A; Albright, J C; Goering, A W; Thomas, P M; Kelleher, N L; Keller, N P; Wu, C C

Fungal artificial chromosomes for mining of the fungal secondary metabolome Journal Article

BMC Genomics, 16 , pp. 343, 2015, ISSN: 1471-2164 (Electronic) 1471-2164 (Linking).

Links | BibTeX | Tags:

Cleland, T P; Schroeter, E R; Zamdborg, L; Zheng, W; Lee, J E; Tran, J C; Bern, M; Duncan, M B; Lebleu, V S; Ahlf, D R; Thomas, P M; Kalluri, R; Kelleher, N L; Schweitzer, M H

Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis Journal Article

J Proteome Res, 14 (12), pp. 5252-62, 2015, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Compton, P D; Fornelli, L; Kelleher, N L; Skinner, O S

Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry Journal Article

Int J Mass Spectrom, 390 , pp. 132-136, 2015, ISSN: 1387-3806 (Print) 1387-3806 (Linking).

Links | BibTeX | Tags:

Dam, D H; Lee, H; Lee, R C; Kim, K H; Kelleher, N L; Odom, T W

Tunable loading of oligonucleotides with secondary structure on gold nanoparticles through a pH-driven method Journal Article

Bioconjug Chem, 26 (2), pp. 279-85, 2015, ISSN: 1520-4812 (Electronic) 1043-1802 (Linking).

Links | BibTeX | Tags:

Durbin, K R; Skinner, O S; Fellers, R T; Kelleher, N L

Analyzing internal fragmentation of electrosprayed ubiquitin ions during beam-type collisional dissociation Journal Article

J Am Soc Mass Spectrom, 26 (5), pp. 782-7, 2015, ISSN: 1879-1123 (Electronic) 1044-0305 (Linking).

Links | BibTeX | Tags:

280 entries « 1 of 6 »