Publications

292 entries « 1 of 6 »

2017

Harris, D; Lukoyanov, D; Shaw, S; Compton, P D; Tokmina-Lukaszewska, M; Bothner, B; Kelleher, N L; Dean, D R; Hoffman, B M; Seefeldt, L C

The Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2 Journal Article

Biochemistry, 2017.

Abstract | Links | BibTeX | Tags:

Rickels, R; Herz, H M; Sze, C C; Cao, K; Morgan, M A; Collings, C K; Gause, M; Takahashi, Y H; Wang, L; Rendleman, E J; Marshall, S A; Krueger, A; Bartom, E T; A. Piunti, ; Smith, E R; Abshiru, N A; Kelleher, N L; Dorsett, D; A.Shilatifard,

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability. Journal Article

Nat. Genet., 49 (11), pp. 1647-1653, 2017.

Abstract | Links | BibTeX | Tags:

S.Turcan, ; V.Makarov, ; J.Taranda, ; Y.Wang, ; Fabius, A W M; W.Wu, ; Y.Zheng, ; N.El-Amine, ; S.Haddock, ; G.Nanjangud, ; H.C.LeKaye, ; C.Brennan, ; J.Cross, ; J.T.Huse, ; Kelleher, N L; P.Osten, ; C.B.Thompson, ; T.A.Chan,

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence. Journal Article

Nat. Genet., 2017.

Abstract | Links | BibTeX | Tags:

Skinner, O S; Haverland, N A; Fornelli, L; Melani, R D; Vale, Do L H F; Seckler, H S; Doubleday, P F; Schachner, L F; Srzentić, K; Kelleher, N L; Compton, P D

Top-down characterization of endogenous protein complexes with native proteomics. Journal Article

Nat. Chem. Biol., 2017.

Abstract | Links | BibTeX | Tags:

Mascarenhas, R; Le, H V; Clevenger, K D; Lehrer, H J; Ringe, D; Kelleher, N L; Silverman, R B; Liu, D

Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Journal Article

Biochemistry, 56 (43), pp. 5844-5845, 2017.

Links | BibTeX | Tags:

Skinner, O S; McAnally, M O; Duyne, Van R P; Schatz, G C; Breuker, K; Compton, P D; Kelleher, N L

Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin Journal Article

Anal. Chem. , 89 (20), pp. 10711-10716, 2017.

Abstract | Links | BibTeX | Tags:

Haverland, N A; Wass, M; Ntai, I; Keppel, T; Gundry, R L; Kelleher, N L

Cell Surface Proteomics of N-Linked Glycoproteins for Typing of Human Lymphocytes Journal Article

Proteomics, 17 (19), 2017.

Abstract | Links | BibTeX | Tags:

Ezponda, T; Dupéré-Richer, D; Will, C M; Small, E C; Varghese, N; Patel, T; Nabet, B; Popovic, R; Oyer, J; Bulic, M; Zheng, Y; Huang, X; Shah, M Y; Maji, S; Riva, A; Occhionorelli, M; Tonon, G; Kelleher, N; Keats, J; Licht, J D

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition Journal Article

Cell. Rep. , 21 (3), pp. 628-640, 2017.

Abstract | Links | BibTeX | Tags:

Zha, L; Jiang, Y; Henke, M T; Wilson, M R; Wang, J X; Kelleher, N L; Balskus, E P

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring. Journal Article

Nat Chem Biol, 13 (10), pp. 1063-1065, 2017.

Abstract | Links | BibTeX | Tags:

Morgan, M A J; Rickels, R A; Collings, C K; He, X; Cao, K; Herz, H M; Cozzolino, K A; Abshiru, N A; Marshall, S A; Rendleman, E J; Sze, C C; Piunti, A; Kelleher, N L; Savas, J N; Shilatifard, A

A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation. Journal Article

Genes. Dev., 19 , pp. 2003-2014, 2017.

Abstract | Links | BibTeX | Tags:

Ichikawa, Y; Connelly, C F; Appleboim, A; Miller, T C; Jacobi, H; Abshiru, N A; Chou, H J; Chen, Y; Sharma, U; Zheng, Y; Thomas, P M; Chen, H V; Bajaj, V; Müller, C W; Kelleher, N L; Friedman, N; Bolon, D N; Rando, O J; Kaufman, P D

A synthetic biology approach to probing nucleosome symmetry Journal Article

eLife, (6), 2017.

Abstract | Links | BibTeX | Tags:

Mascarenhas, R; Le, H V; Clevenger, K D; Lehrer, H J; Ringe, D; Kelleher, N L; Silverman, R B; Liu, D

Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Journal Article

Biochemistry, 56 (37), pp. 4951-4961, 2017.

Abstract | Links | BibTeX | Tags:

Wildburger, N C; Esparza, T J; LeDuc, R D; Fellers, R T; Thomas, P M; Cairns, N J; Kelleher, N L; Bateman, R J; Brody, D L

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain Journal Article

Sci. Rep. , 7 (1), pp. 9520, 2017.

Abstract | Links | BibTeX | Tags:

Zhou, Y; Zhang, X; Fornelli, L; Compton, P D; Kelleher, N; Wirth, M J

Chromatographic efficiency and selectivity in top-down proteomics of histones. Journal Article

J Chromatogr B Analyt Technol Biomed Life Sci, pp. 47-53, 2017.

Abstract | Links | BibTeX | Tags:

Anderson, L C; DeHart, C J; Kaiser, N K; Fellers, R T; Smith, D F; Greer, J B; LeDuc, R D; Blakney, G T; Thomas, P M; Kelleher, N L; Hendrickson, C L

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry Journal Article

J Proteome Res, 16 (2), pp. 1087-1096, 2017, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Cleland, T P; DeHart, C J; Fellers, R T; VanNispen, A J; Greer, J B; LeDuc, R D; Parker, W R; Thomas, P M; Kelleher, N L; Brodbelt, J S

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer Journal Article

J Proteome Res, 16 (5), pp. 2072-2079, 2017, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Clevenger, K D; Bok, J W; Ye, R; Miley, G P; Verdan, M H; Velk, T; Chen, C; Yang, K; Robey, M T; Gao, P; Lamprecht, M; Thomas, P M; Islam, M N; Palmer, J M; Wu, C C; Keller, N P; Kelleher, N L

A scalable platform to identify fungal secondary metabolites and their gene clusters Journal Article

Nat Chem Biol, 2017, ISSN: 1552-4469 (Electronic) 1552-4450 (Linking).

Links | BibTeX | Tags:

Clevenger, K D; Mascarenhas, R; Catlin, D; Wu, R; Kelleher, N L; Drake, E J; Gulick, A M; Liu, D; Fast, W

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ Journal Article

ACS Chem Biol, 12 (3), pp. 643-647, 2017, ISSN: 1554-8937 (Electronic) 1554-8929 (Linking).

Links | BibTeX | Tags:

DeHart, C J; Fellers, R T; Fornelli, L; Kelleher, N L; Thomas, P M

Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite Journal Article

Methods Mol Biol, 1558 , pp. 381-394, 2017, ISSN: 1940-6029 (Electronic) 1064-3745 (Linking).

Links | BibTeX | Tags:

Fornelli, L; Durbin, K R; Fellers, R T; Early, B P; Greer, J B; LeDuc, R D; Compton, P D; Kelleher, N L

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer Journal Article

J Proteome Res, 16 (2), pp. 609-618, 2017, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Fornelli, L; Toby, T K; Schachner, L F; Doubleday, P F; Srzentic, K; DeHart, C J; Kelleher, N L

Top-down proteomics: Where we are, where we are going? Journal Article

J Proteomics, 2017, ISSN: 1876-7737 (Electronic) 1874-3919 (Linking).

Links | BibTeX | Tags:

Gan, R; Perez, J G; Carlson, E D; Ntai, I; Isaacs, F J; Kelleher, N L; Jewett, M C

Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins Journal Article

Biotechnol Bioeng, 114 (5), pp. 1074-1086, 2017, ISSN: 1097-0290 (Electronic) 0006-3592 (Linking).

Links | BibTeX | Tags:

Goering, A W; Li, J; McClure, R A; Thomson, R J; Jewett, M C; Kelleher, N L

In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis Journal Article

ACS Synth Biol, 6 (1), pp. 39-44, 2017, ISSN: 2161-5063 (Electronic) 2161-5063 (Linking).

Links | BibTeX | Tags:

Greer, S M; Holden, D D; Fellers, R; Kelleher, N L; Brodbelt, J S

Modulation of Protein Fragmentation Through Carbamylation of Primary Amines Journal Article

J Am Soc Mass Spectrom, 28 (8), pp. 1587-1599, 2017, ISSN: 1879-1123 (Electronic) 1044-0305 (Linking).

Links | BibTeX | Tags:

Haverland, N A; Skinner, O S; Fellers, R T; Tariq, A A; Early, B P; LeDuc, R D; Fornelli, L; Compton, P D; Kelleher, N L

Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry Journal Article

J Am Soc Mass Spectrom, 28 (6), pp. 1203-1215, 2017, ISSN: 1879-1123 (Electronic) 1044-0305 (Linking).

Links | BibTeX | Tags:

Mandacaru, S C; do Vale, L H; Vahidi, S; Xiao, Y; Skinner, O S; Ricart, C A; Kelleher, N L; de Sousa, M V; Konermann, L

Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools Journal Article

Biochemistry, 56 (11), pp. 1645-1655, 2017, ISSN: 1520-4995 (Electronic) 0006-2960 (Linking).

Links | BibTeX | Tags:

Piunti, A; Hashizume, R; Morgan, M A; Bartom, E T; Horbinski, C M; Marshall, S A; Rendleman, E J; Ma, Q; Takahashi, Y H; Woodfin, A R; Misharin, A V; Abshiru, N A; Lulla, R R; Saratsis, A M; Kelleher, N L; James, C D; Shilatifard, A

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas Journal Article

Nat Med, 23 (4), pp. 493-500, 2017, ISSN: 1546-170X (Electronic) 1078-8956 (Linking).

Links | BibTeX | Tags:

Schroeter, E R; DeHart, C J; Cleland, T P; Zheng, W; Thomas, P M; Kelleher, N L; Bern, M; Schweitzer, M H

Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein Journal Article

J Proteome Res, 16 (2), pp. 920-932, 2017, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Toby, T K; Abecassis, M M; Kim, K; Thomas, P M; Fellers, R T; LeDuc, R D; Kelleher, N L; Demetris, J; Levitsky, J

Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients Journal Article

Am J Transplant, 2017, ISSN: 1600-6143 (Electronic) 1600-6135 (Linking).

Links | BibTeX | Tags:

2016

Chen, Y; McClure, R A; Kelleher, N L

Screening for Expressed Nonribosomal Peptide Synthetases and Polyketide Synthases Using LC-MS/MS-Based Proteomics Journal Article

Methods Mol Biol, 1401 , pp. 135-47, 2016, ISSN: 1940-6029 (Electronic) 1064-3745 (Linking).

Links | BibTeX | Tags:

Durbin, K R; Fornelli, L; Fellers, R T; Doubleday, P F; Narita, M; Kelleher, N L

Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa Journal Article

J Proteome Res, 15 (3), pp. 976-82, 2016, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

Goering, A W; McClure, R A; Doroghazi, J R; Albright, J C; Haverland, N A; Zhang, Y; Ju, K S; Thomson, R J; Metcalf, W W; Kelleher, N L

Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer Journal Article

ACS Cent Sci, 2 (2), pp. 99-108, 2016, ISSN: 2374-7943 (Print) 2374-7943 (Linking).

Links | BibTeX | Tags:

Gunn, B; Schneider, J; Shansab, M; Bastian, A R; Fahrbach, K; th Smith, A; Mahan, A; Karim, M; Licht, A; Zvonar, I; Tedesco, J; Anderson, M; Chapel, A; Suscovich, T; Malaspina, D; Streeck, H; Walker, B D; Kim, A; Lauer, G; Altfeld, M; Pillai, S; Szleifer, I; Kelleher, N L; Kiser, P F; Hope, T J; Alter, G

Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16 Journal Article

Mucosal Immunol, 9 (6), pp. 1549-1558, 2016, ISSN: 1935-3456 (Electronic) 1933-0219 (Linking).

Links | BibTeX | Tags:

Hattori, T; Lai, D; Dementieva, I S; Montano, S P; Kurosawa, K; Zheng, Y; Akin, L R; Swist-Rosowska, K M; Grzybowski, A T; Koide, A; Krajewski, K; Strahl, B D; Kelleher, N L; Ruthenburg, A J; Koide, S

Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation Journal Article

Proc Natl Acad Sci U S A, 113 (8), pp. 2092-7, 2016, ISSN: 1091-6490 (Electronic) 0027-8424 (Linking).

Links | BibTeX | Tags:

Henke, M T; Kelleher, N L

Modern mass spectrometry for synthetic biology and structure-based discovery of natural products Journal Article

Nat Prod Rep, 33 (8), pp. 942-50, 2016, ISSN: 1460-4752 (Electronic) 0265-0568 (Linking).

Links | BibTeX | Tags:

Henke, M T; Soukup, A A; Goering, A W; McClure, R A; Thomson, R J; Keller, N P; Kelleher, N L

New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans Journal Article

ACS Chem Biol, 11 (8), pp. 2117-23, 2016, ISSN: 1554-8937 (Electronic) 1554-8929 (Linking).

Links | BibTeX | Tags:

Kenney, G E; Goering, A W; Ross, M O; DeHart, C J; Thomas, P M; Hoffman, B M; Kelleher, N L; Rosenzweig, A C

Characterization of Methanobactin from Methylosinus sp. LW4 Journal Article

J Am Chem Soc, 138 (35), pp. 11124-7, 2016, ISSN: 1520-5126 (Electronic) 0002-7863 (Linking).

Links | BibTeX | Tags:

LaFave, L M; Beguelin, W; Koche, R; Teater, M; Spitzer, B; Chramiec, A; Papalexi, E; Keller, M D; Hricik, T; Konstantinoff, K; Micol, J B; Durham, B; Knutson, S K; Campbell, J E; Blum, G; Shi, X; Doud, E H; Krivtsov, A V; Chung, Y R; Khodos, I; de Stanchina, E; Ouerfelli, O; Adusumilli, P S; Thomas, P M; Kelleher, N L; Luo, M; Keilhack, H; Abdel-Wahab, O; Melnick, A; Armstrong, S A; Levine, R L

Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status" Journal Article

Nat Med, 22 (6), pp. 578-9, 2016, ISSN: 1546-170X (Electronic) 1078-8956 (Linking).

Links | BibTeX | Tags:

Liu, F; Koval, M; Ranganathan, S; Fanayan, S; Hancock, W S; Lundberg, E K; Beavis, R C; Lane, L; Duek, P; McQuade, L; Kelleher, N L; Baker, M S

Systems Proteomics View of the Endogenous Human Claudin Protein Family Journal Article

J Proteome Res, 15 (2), pp. 339-59, 2016, ISSN: 1535-3907 (Electronic) 1535-3893 (Linking).

Links | BibTeX | Tags:

McClure, R A; Goering, A W; Ju, K S; Baccile, J A; Schroeder, F C; Metcalf, W W; Thomson, R J; Kelleher, N L

Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations Journal Article

ACS Chem Biol, 11 (12), pp. 3452-3460, 2016, ISSN: 1554-8937 (Electronic) 1554-8929 (Linking).

Links | BibTeX | Tags:

Melani, R D; Seckler, H S; Skinner, O S; Vale, Do L H; Catherman, A D; Havugimana, P C; de Sousa, Valle M; Domont, G B; Kelleher, N L; Compton, P D

CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis Journal Article

J Vis Exp, (108), pp. 53597, 2016, ISSN: 1940-087X (Electronic) 1940-087X (Linking).

Links | BibTeX | Tags:

Melani, R D; Skinner, O S; Fornelli, L; Domont, G B; Compton, P D; Kelleher, N L

Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics Journal Article

Mol Cell Proteomics, 15 (7), pp. 2423-34, 2016, ISSN: 1535-9484 (Electronic) 1535-9476 (Linking).

Links | BibTeX | Tags:

Moussazadeh, N; Berman, S H; Laufer, I; Gounder, M; Zheng, Y; Sommer, J; Bilsky, M H; Kelleher, N L; Brennan, C

365 Epigenetic Profiling Reveals a Unique Histone Code in Chordoma Journal Article

Neurosurgery, 63 Suppl 1 , pp. 208, 2016, ISSN: 1524-4040 (Electronic) 0148-396X (Linking).

Links | BibTeX | Tags:

Ntai, I; LeDuc, R D; Fellers, R T; Erdmann-Gilmore, P; Davies, S R; Rumsey, J; Early, B P; Thomas, P M; Li, S; Compton, P D; Ellis, M J; Ruggles, K V; Fenyo, D; Boja, E S; Rodriguez, H; Townsend, R R; Kelleher, N L

Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts Journal Article

Mol Cell Proteomics, 15 (1), pp. 45-56, 2016, ISSN: 1535-9484 (Electronic) 1535-9476 (Linking).

Links | BibTeX | Tags:

Ntai, I; Toby, T K; LeDuc, R D; Kelleher, N L

A Method for Label-Free, Differential Top-Down Proteomics Journal Article

Methods Mol Biol, 1410 , pp. 121-33, 2016, ISSN: 1940-6029 (Electronic) 1064-3745 (Linking).

Links | BibTeX | Tags:

Ong, T H; Romanova, E V; Roberts-Galbraith, R H; Yang, N; Zimmerman, T A; Collins, 3rd J J; Lee, J E; Kelleher, N L; Newmark, P A; Sweedler, J V

Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea Journal Article

J Biol Chem, 291 (15), pp. 8109-20, 2016, ISSN: 1083-351X (Electronic) 0021-9258 (Linking).

Links | BibTeX | Tags:

Savaryn, J P; Skinner, O S; Fornelli, L; Fellers, R T; Compton, P D; Terhune, S S; Abecassis, M M; Kelleher, N L

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry Journal Article

J Proteomics, 134 , pp. 76-84, 2016, ISSN: 1876-7737 (Electronic) 1874-3919 (Linking).

Links | BibTeX | Tags:

Savaryn, J P; Toby, T K; Catherman, A D; Fellers, R T; LeDuc, R D; Thomas, P M; Friedewald, J J; Salomon, D R; Abecassis, M M; Kelleher, N L

Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection Journal Article

Proteomics, 16 (14), pp. 2048-58, 2016, ISSN: 1615-9861 (Electronic) 1615-9853 (Linking).

Links | BibTeX | Tags:

Savaryn, J P; Toby, T K; Kelleher, N L

A researcher's guide to mass spectrometry-based proteomics Journal Article

Proteomics, 16 (18), pp. 2435-43, 2016, ISSN: 1615-9861 (Electronic) 1615-9853 (Linking).

Links | BibTeX | Tags:

Schroeter, E R; DeHart, C J; Schweitzer, M H; Thomas, P M; Kelleher, N L

Bone protein "extractomics": comparing the efficiency of bone protein extractions of Gallus gallus in tandem mass spectrometry, with an eye towards paleoproteomics Journal Article

PeerJ, 4 , pp. e2603, 2016, ISSN: 2167-8359 (Print).

Links | BibTeX | Tags:

292 entries « 1 of 6 »