2017
|
Zha, L; Y.Jiang, ; amd Wilson, M.T.Henke M R; J.X.Wang, ; N.L.Kelleher, ; E.P.Balskus, Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring. Journal Article Nat Chem Biol, 13 (10), pp. 1063-1065, 2017. Abstract | Links | BibTeX | Tags: @article{Zha2017,
title = {Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.},
author = {L. Zha and Y.Jiang and M.T.Henke amd M.R. Wilson and J.X.Wang and N.L.Kelleher and E.P.Balskus},
url = {http://dx.doi.org/10.1038/nchembio.2448},
doi = {10.1038/nchembio.2448},
year = {2017},
date = {2017-10-01},
journal = {Nat Chem Biol},
volume = {13},
number = {10},
pages = {1063-1065},
abstract = {Despite containing an α-amino acid, the versatile cofactor S-adenosylmethionine (SAM) is not a known building block for nonribosomal peptide synthetase (NRPS) assembly lines. Here we report an unusual NRPS module from colibactin biosynthesis that uses SAM for amide bond formation and subsequent cyclopropanation. Our findings showcase a new use for SAM and reveal a novel biosynthetic route to a functional group that likely mediates colibactin's genotoxicity.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Despite containing an α-amino acid, the versatile cofactor S-adenosylmethionine (SAM) is not a known building block for nonribosomal peptide synthetase (NRPS) assembly lines. Here we report an unusual NRPS module from colibactin biosynthesis that uses SAM for amide bond formation and subsequent cyclopropanation. Our findings showcase a new use for SAM and reveal a novel biosynthetic route to a functional group that likely mediates colibactin's genotoxicity. |
Mascarenhas, R; Le, H V; Clevenger, K D; Lehrer, H J; Ringe, D; Kelleher, N L; Silverman, R B; Liu, D Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Journal Article Biochemistry, 56 (37), pp. 4951-4961, 2017. Abstract | Links | BibTeX | Tags: @article{Mascarenhas2017,
title = {Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.},
author = {R. Mascarenhas and H.V. Le and K.D. Clevenger and H.J. Lehrer and D. Ringe and N.L. Kelleher and R.B. Silverman and D. Liu},
url = {https://dx.doi.org/10.1021/acs.biochem.7b00499},
doi = {10.1021/acs.biochem.7b00499},
year = {2017},
date = {2017-09-06},
journal = {Biochemistry},
volume = {56},
number = {37},
pages = {4951-4961},
abstract = {Potent mechanism-based inactivators can be rationally designed against pyridoxal 5'-phosphate (PLP)-dependent drug targets, such as ornithine aminotransferase (OAT) or γ-aminobutyric acid aminotransferase (GABA-AT). An important challenge, however, is the lack of selectivity toward other PLP-dependent, off-target enzymes, because of similarities in mechanisms of all PLP-dependent aminotransferase reactions. On the basis of complex crystal structures, we investigate the inactivation mechanism of OAT, a hepatocellular carcinoma target, by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP), a known inactivator of GABA-AT. A crystal structure of OAT and FCP showed the formation of a ternary adduct. This adduct can be rationalized as occurring via an enamine mechanism of inactivation, similar to that reported for GABA-AT. However, the crystal structure of an off-target, PLP-dependent enzyme, aspartate aminotransferase (Asp-AT), in complex with FCP, along with the results of attempted inhibition assays, suggests that FCP is not an inactivator of Asp-AT, but rather an alternate substrate. Turnover of FCP by Asp-AT is also supported by high-resolution mass spectrometry. Amid existing difficulties in achieving selectivity of inactivation among a large number of PLP-dependent enzymes, the obtained results provide evidence that a desirable selectivity could be achieved, taking advantage of subtle structural and mechanistic differences between a drug-target enzyme and an off-target enzyme, despite their largely similar substrate binding sites and catalytic mechanisms.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Potent mechanism-based inactivators can be rationally designed against pyridoxal 5'-phosphate (PLP)-dependent drug targets, such as ornithine aminotransferase (OAT) or γ-aminobutyric acid aminotransferase (GABA-AT). An important challenge, however, is the lack of selectivity toward other PLP-dependent, off-target enzymes, because of similarities in mechanisms of all PLP-dependent aminotransferase reactions. On the basis of complex crystal structures, we investigate the inactivation mechanism of OAT, a hepatocellular carcinoma target, by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP), a known inactivator of GABA-AT. A crystal structure of OAT and FCP showed the formation of a ternary adduct. This adduct can be rationalized as occurring via an enamine mechanism of inactivation, similar to that reported for GABA-AT. However, the crystal structure of an off-target, PLP-dependent enzyme, aspartate aminotransferase (Asp-AT), in complex with FCP, along with the results of attempted inhibition assays, suggests that FCP is not an inactivator of Asp-AT, but rather an alternate substrate. Turnover of FCP by Asp-AT is also supported by high-resolution mass spectrometry. Amid existing difficulties in achieving selectivity of inactivation among a large number of PLP-dependent enzymes, the obtained results provide evidence that a desirable selectivity could be achieved, taking advantage of subtle structural and mechanistic differences between a drug-target enzyme and an off-target enzyme, despite their largely similar substrate binding sites and catalytic mechanisms. |
Anderson, L C; DeHart, C J; Kaiser, N K; Fellers, R T; Smith, D F; Greer, J B; LeDuc, R D; Blakney, G T; Thomas, P M; Kelleher, N L; Hendrickson, C L Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry Journal Article J Proteome Res, 16 (2), pp. 1087-1096, 2017, ISSN: 1535-3907 (Electronic)
1535-3893 (Linking). Links | BibTeX | Tags: @article{RN469,
title = {Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry},
author = { L. C. Anderson and C. J. DeHart and N. K. Kaiser and R. T. Fellers and D. F. Smith and J. B. Greer and R. D. LeDuc and G. T. Blakney and P. M. Thomas and N. L. Kelleher and C. L. Hendrickson},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27936753},
doi = {10.1021/acs.jproteome.6b00696},
issn = {1535-3907 (Electronic)
1535-3893 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {J Proteome Res},
volume = {16},
number = {2},
pages = {1087-1096},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Cleland, T P; DeHart, C J; Fellers, R T; VanNispen, A J; Greer, J B; LeDuc, R D; Parker, W R; Thomas, P M; Kelleher, N L; Brodbelt, J S High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer Journal Article J Proteome Res, 16 (5), pp. 2072-2079, 2017, ISSN: 1535-3907 (Electronic)
1535-3893 (Linking). Links | BibTeX | Tags: @article{RN458,
title = {High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer},
author = { T. P. Cleland and C. J. DeHart and R. T. Fellers and A. J. VanNispen and J. B. Greer and R. D. LeDuc and W. R. Parker and P. M. Thomas and N. L. Kelleher and J. S. Brodbelt},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28412815},
doi = {10.1021/acs.jproteome.7b00043},
issn = {1535-3907 (Electronic)
1535-3893 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {J Proteome Res},
volume = {16},
number = {5},
pages = {2072-2079},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Clevenger, K D; Bok, J W; Ye, R; Miley, G P; Verdan, M H; Velk, T; Chen, C; Yang, K; Robey, M T; Gao, P; Lamprecht, M; Thomas, P M; Islam, M N; Palmer, J M; Wu, C C; Keller, N P; Kelleher, N L A scalable platform to identify fungal secondary metabolites and their gene clusters Journal Article Nat Chem Biol, 2017, ISSN: 1552-4469 (Electronic)
1552-4450 (Linking). Links | BibTeX | Tags: @article{RN456,
title = {A scalable platform to identify fungal secondary metabolites and their gene clusters},
author = { K. D. Clevenger and J. W. Bok and R. Ye and G. P. Miley and M. H. Verdan and T. Velk and C. Chen and K. Yang and M. T. Robey and P. Gao and M. Lamprecht and P. M. Thomas and M. N. Islam and J. M. Palmer and C. C. Wu and N. P. Keller and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28604695},
doi = {10.1038/nchembio.2408},
issn = {1552-4469 (Electronic)
1552-4450 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Nat Chem Biol},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Clevenger, K D; Mascarenhas, R; Catlin, D; Wu, R; Kelleher, N L; Drake, E J; Gulick, A M; Liu, D; Fast, W Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ Journal Article ACS Chem Biol, 12 (3), pp. 643-647, 2017, ISSN: 1554-8937 (Electronic)
1554-8929 (Linking). Links | BibTeX | Tags: @article{RN464,
title = {Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ},
author = { K. D. Clevenger and R. Mascarenhas and D. Catlin and R. Wu and N. L. Kelleher and E. J. Drake and A. M. Gulick and D. Liu and W. Fast},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28186406},
doi = {10.1021/acschembio.7b00031},
issn = {1554-8937 (Electronic)
1554-8929 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {ACS Chem Biol},
volume = {12},
number = {3},
pages = {643-647},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
DeHart, C J; Fellers, R T; Fornelli, L; Kelleher, N L; Thomas, P M Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite Journal Article Methods Mol Biol, 1558 , pp. 381-394, 2017, ISSN: 1940-6029 (Electronic)
1064-3745 (Linking). Links | BibTeX | Tags: @article{RN466,
title = {Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite},
author = { C. J. DeHart and R. T. Fellers and L. Fornelli and N. L. Kelleher and P. M. Thomas},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28150248},
doi = {10.1007/978-1-4939-6783-4_18},
issn = {1940-6029 (Electronic)
1064-3745 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Methods Mol Biol},
volume = {1558},
pages = {381-394},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Fornelli, L; Durbin, K R; Fellers, R T; Early, B P; Greer, J B; LeDuc, R D; Compton, P D; Kelleher, N L Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer Journal Article J Proteome Res, 16 (2), pp. 609-618, 2017, ISSN: 1535-3907 (Electronic)
1535-3893 (Linking). Links | BibTeX | Tags: @article{RN465,
title = {Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer},
author = { L. Fornelli and K. R. Durbin and R. T. Fellers and B. P. Early and J. B. Greer and R. D. LeDuc and P. D. Compton and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28152595},
doi = {10.1021/acs.jproteome.6b00698},
issn = {1535-3907 (Electronic)
1535-3893 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {J Proteome Res},
volume = {16},
number = {2},
pages = {609-618},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Fornelli, L; Toby, T K; Schachner, L F; Doubleday, P F; Srzentic, K; DeHart, C J; Kelleher, N L Top-down proteomics: Where we are, where we are going? Journal Article J Proteomics, 2017, ISSN: 1876-7737 (Electronic)
1874-3919 (Linking). Links | BibTeX | Tags: @article{RN463,
title = {Top-down proteomics: Where we are, where we are going?},
author = { L. Fornelli and T. K. Toby and L. F. Schachner and P. F. Doubleday and K. Srzentic and C. J. DeHart and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28188863},
doi = {10.1016/j.jprot.2017.02.002},
issn = {1876-7737 (Electronic)
1874-3919 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {J Proteomics},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Gan, R; Perez, J G; Carlson, E D; Ntai, I; Isaacs, F J; Kelleher, N L; Jewett, M C Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins Journal Article Biotechnol Bioeng, 114 (5), pp. 1074-1086, 2017, ISSN: 1097-0290 (Electronic)
0006-3592 (Linking). Links | BibTeX | Tags: @article{RN468,
title = {Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins},
author = { R. Gan and J. G. Perez and E. D. Carlson and I. Ntai and F. J. Isaacs and N. L. Kelleher and M. C. Jewett},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27987323},
doi = {10.1002/bit.26239},
issn = {1097-0290 (Electronic)
0006-3592 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Biotechnol Bioeng},
volume = {114},
number = {5},
pages = {1074-1086},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Goering, A W; Li, J; McClure, R A; Thomson, R J; Jewett, M C; Kelleher, N L In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis Journal Article ACS Synth Biol, 6 (1), pp. 39-44, 2017, ISSN: 2161-5063 (Electronic)
2161-5063 (Linking). Links | BibTeX | Tags: @article{RN475,
title = {In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis},
author = { A. W. Goering and J. Li and R. A. McClure and R. J. Thomson and M. C. Jewett and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27478992},
doi = {10.1021/acssynbio.6b00160},
issn = {2161-5063 (Electronic)
2161-5063 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {ACS Synth Biol},
volume = {6},
number = {1},
pages = {39-44},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Greer, S M; Holden, D D; Fellers, R; Kelleher, N L; Brodbelt, J S Modulation of Protein Fragmentation Through Carbamylation of Primary Amines Journal Article J Am Soc Mass Spectrom, 28 (8), pp. 1587-1599, 2017, ISSN: 1879-1123 (Electronic)
1044-0305 (Linking). Links | BibTeX | Tags: @article{RN459,
title = {Modulation of Protein Fragmentation Through Carbamylation of Primary Amines},
author = { S. M. Greer and D. D. Holden and R. Fellers and N. L. Kelleher and J. S. Brodbelt},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28374316},
doi = {10.1007/s13361-017-1648-5},
issn = {1879-1123 (Electronic)
1044-0305 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {J Am Soc Mass Spectrom},
volume = {28},
number = {8},
pages = {1587-1599},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Haverland, N A; Skinner, O S; Fellers, R T; Tariq, A A; Early, B P; LeDuc, R D; Fornelli, L; Compton, P D; Kelleher, N L Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry Journal Article J Am Soc Mass Spectrom, 28 (6), pp. 1203-1215, 2017, ISSN: 1879-1123 (Electronic)
1044-0305 (Linking). Links | BibTeX | Tags: @article{RN460,
title = {Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry},
author = { N. A. Haverland and O. S. Skinner and R. T. Fellers and A. A. Tariq and B. P. Early and R. D. LeDuc and L. Fornelli and P. D. Compton and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28374312},
doi = {10.1007/s13361-017-1635-x},
issn = {1879-1123 (Electronic)
1044-0305 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {J Am Soc Mass Spectrom},
volume = {28},
number = {6},
pages = {1203-1215},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Mandacaru, S C; do Vale, L H; Vahidi, S; Xiao, Y; Skinner, O S; Ricart, C A; Kelleher, N L; de Sousa, M V; Konermann, L Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools Journal Article Biochemistry, 56 (11), pp. 1645-1655, 2017, ISSN: 1520-4995 (Electronic)
0006-2960 (Linking). Links | BibTeX | Tags: @article{RN462,
title = {Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools},
author = { S. C. Mandacaru and L. H. do Vale and S. Vahidi and Y. Xiao and O. S. Skinner and C. A. Ricart and N. L. Kelleher and M. V. de Sousa and L. Konermann},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28252287},
doi = {10.1021/acs.biochem.7b00020},
issn = {1520-4995 (Electronic)
0006-2960 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Biochemistry},
volume = {56},
number = {11},
pages = {1645-1655},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Piunti, A; Hashizume, R; Morgan, M A; Bartom, E T; Horbinski, C M; Marshall, S A; Rendleman, E J; Ma, Q; Takahashi, Y H; Woodfin, A R; Misharin, A V; Abshiru, N A; Lulla, R R; Saratsis, A M; Kelleher, N L; James, C D; Shilatifard, A Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas Journal Article Nat Med, 23 (4), pp. 493-500, 2017, ISSN: 1546-170X (Electronic)
1078-8956 (Linking). Links | BibTeX | Tags: @article{RN461,
title = {Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas},
author = { A. Piunti and R. Hashizume and M. A. Morgan and E. T. Bartom and C. M. Horbinski and S. A. Marshall and E. J. Rendleman and Q. Ma and Y. H. Takahashi and A. R. Woodfin and A. V. Misharin and N. A. Abshiru and R. R. Lulla and A. M. Saratsis and N. L. Kelleher and C. D. James and A. Shilatifard},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28263307},
doi = {10.1038/nm.4296},
issn = {1546-170X (Electronic)
1078-8956 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Nat Med},
volume = {23},
number = {4},
pages = {493-500},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Schroeter, E R; DeHart, C J; Cleland, T P; Zheng, W; Thomas, P M; Kelleher, N L; Bern, M; Schweitzer, M H Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein Journal Article J Proteome Res, 16 (2), pp. 920-932, 2017, ISSN: 1535-3907 (Electronic)
1535-3893 (Linking). Links | BibTeX | Tags: @article{RN467,
title = {Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein},
author = { E. R. Schroeter and C. J. DeHart and T. P. Cleland and W. Zheng and P. M. Thomas and N. L. Kelleher and M. Bern and M. H. Schweitzer},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28111950},
doi = {10.1021/acs.jproteome.6b00873},
issn = {1535-3907 (Electronic)
1535-3893 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {J Proteome Res},
volume = {16},
number = {2},
pages = {920-932},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Toby, T K; Abecassis, M M; Kim, K; Thomas, P M; Fellers, R T; LeDuc, R D; Kelleher, N L; Demetris, J; Levitsky, J Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients Journal Article Am J Transplant, 2017, ISSN: 1600-6143 (Electronic) 1600-6135 (Linking). Links | BibTeX | Tags: @article{RN457,
title = {Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients},
author = { T. K. Toby and M. M. Abecassis and K. Kim and P. M. Thomas and R. T. Fellers and R. D. LeDuc and N. L. Kelleher and J. Demetris and J. Levitsky},
url = {http://www.ncbi.nlm.nih.gov/pubmed/28510335},
doi = {10.1111/ajt.14359},
issn = {1600-6143 (Electronic) 1600-6135 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Am J Transplant},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2016
|
Chen, Y; McClure, R A; Kelleher, N L Screening for Expressed Nonribosomal Peptide Synthetases and Polyketide Synthases Using LC-MS/MS-Based Proteomics Journal Article Methods Mol Biol, 1401 , pp. 135-47, 2016, ISSN: 1940-6029 (Electronic)
1064-3745 (Linking). Links | BibTeX | Tags: @article{RN490,
title = {Screening for Expressed Nonribosomal Peptide Synthetases and Polyketide Synthases Using LC-MS/MS-Based Proteomics},
author = { Y. Chen and R. A. McClure and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26831706},
doi = {10.1007/978-1-4939-3375-4_9},
issn = {1940-6029 (Electronic)
1064-3745 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Methods Mol Biol},
volume = {1401},
pages = {135-47},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Durbin, K R; Fornelli, L; Fellers, R T; Doubleday, P F; Narita, M; Kelleher, N L Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa Journal Article J Proteome Res, 15 (3), pp. 976-82, 2016, ISSN: 1535-3907 (Electronic)
1535-3893 (Linking). Links | BibTeX | Tags: @article{RN491,
title = {Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa},
author = { K. R. Durbin and L. Fornelli and R. T. Fellers and P. F. Doubleday and M. Narita and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26795204},
doi = {10.1021/acs.jproteome.5b00997},
issn = {1535-3907 (Electronic)
1535-3893 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {J Proteome Res},
volume = {15},
number = {3},
pages = {976-82},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Goering, A W; McClure, R A; Doroghazi, J R; Albright, J C; Haverland, N A; Zhang, Y; Ju, K S; Thomson, R J; Metcalf, W W; Kelleher, N L Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer Journal Article ACS Cent Sci, 2 (2), pp. 99-108, 2016, ISSN: 2374-7943 (Print)
2374-7943 (Linking). Links | BibTeX | Tags: @article{RN483,
title = {Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer},
author = { A. W. Goering and R. A. McClure and J. R. Doroghazi and J. C. Albright and N. A. Haverland and Y. Zhang and K. S. Ju and R. J. Thomson and W. W. Metcalf and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27163034},
doi = {10.1021/acscentsci.5b00331},
issn = {2374-7943 (Print)
2374-7943 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {ACS Cent Sci},
volume = {2},
number = {2},
pages = {99-108},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Gunn, B; Schneider, J; Shansab, M; Bastian, A R; Fahrbach, K; th Smith, A; Mahan, A; Karim, M; Licht, A; Zvonar, I; Tedesco, J; Anderson, M; Chapel, A; Suscovich, T; Malaspina, D; Streeck, H; Walker, B D; Kim, A; Lauer, G; Altfeld, M; Pillai, S; Szleifer, I; Kelleher, N L; Kiser, P F; Hope, T J; Alter, G Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16 Journal Article Mucosal Immunol, 9 (6), pp. 1549-1558, 2016, ISSN: 1935-3456 (Electronic)
1933-0219 (Linking). Links | BibTeX | Tags: @article{RN486,
title = {Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16},
author = { B. Gunn and J. Schneider and M. Shansab and A. R. Bastian and K. Fahrbach and A. th Smith and A. Mahan and M. Karim and A. Licht and I. Zvonar and J. Tedesco and M. Anderson and A. Chapel and T. Suscovich and D. Malaspina and H. Streeck and B. D. Walker and A. Kim and G. Lauer and M. Altfeld and S. Pillai and I. Szleifer and N. L. Kelleher and P. F. Kiser and T. J. Hope and G. Alter},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26960182},
doi = {10.1038/mi.2016.8},
issn = {1935-3456 (Electronic)
1933-0219 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Mucosal Immunol},
volume = {9},
number = {6},
pages = {1549-1558},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Hattori, T; Lai, D; Dementieva, I S; Montano, S P; Kurosawa, K; Zheng, Y; Akin, L R; Swist-Rosowska, K M; Grzybowski, A T; Koide, A; Krajewski, K; Strahl, B D; Kelleher, N L; Ruthenburg, A J; Koide, S Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation Journal Article Proc Natl Acad Sci U S A, 113 (8), pp. 2092-7, 2016, ISSN: 1091-6490 (Electronic)
0027-8424 (Linking). Links | BibTeX | Tags: @article{RN489,
title = {Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation},
author = { T. Hattori and D. Lai and I. S. Dementieva and S. P. Montano and K. Kurosawa and Y. Zheng and L. R. Akin and K. M. Swist-Rosowska and A. T. Grzybowski and A. Koide and K. Krajewski and B. D. Strahl and N. L. Kelleher and A. J. Ruthenburg and S. Koide},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26862167},
doi = {10.1073/pnas.1522691113},
issn = {1091-6490 (Electronic)
0027-8424 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Proc Natl Acad Sci U S A},
volume = {113},
number = {8},
pages = {2092-7},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Henke, M T; Kelleher, N L Modern mass spectrometry for synthetic biology and structure-based discovery of natural products Journal Article Nat Prod Rep, 33 (8), pp. 942-50, 2016, ISSN: 1460-4752 (Electronic)
0265-0568 (Linking). Links | BibTeX | Tags: @article{RN477,
title = {Modern mass spectrometry for synthetic biology and structure-based discovery of natural products},
author = { M. T. Henke and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27376415},
doi = {10.1039/c6np00024j},
issn = {1460-4752 (Electronic)
0265-0568 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Nat Prod Rep},
volume = {33},
number = {8},
pages = {942-50},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Henke, M T; Soukup, A A; Goering, A W; McClure, R A; Thomson, R J; Keller, N P; Kelleher, N L New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans Journal Article ACS Chem Biol, 11 (8), pp. 2117-23, 2016, ISSN: 1554-8937 (Electronic)
1554-8929 (Linking). Links | BibTeX | Tags: @article{RN479,
title = {New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans},
author = { M. T. Henke and A. A. Soukup and A. W. Goering and R. A. McClure and R. J. Thomson and N. P. Keller and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27310134},
doi = {10.1021/acschembio.6b00398},
issn = {1554-8937 (Electronic)
1554-8929 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {ACS Chem Biol},
volume = {11},
number = {8},
pages = {2117-23},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kenney, G E; Goering, A W; Ross, M O; DeHart, C J; Thomas, P M; Hoffman, B M; Kelleher, N L; Rosenzweig, A C Characterization of Methanobactin from Methylosinus sp. LW4 Journal Article J Am Chem Soc, 138 (35), pp. 11124-7, 2016, ISSN: 1520-5126 (Electronic)
0002-7863 (Linking). Links | BibTeX | Tags: @article{RN474,
title = {Characterization of Methanobactin from Methylosinus sp. LW4},
author = { G. E. Kenney and A. W. Goering and M. O. Ross and C. J. DeHart and P. M. Thomas and B. M. Hoffman and N. L. Kelleher and A. C. Rosenzweig},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27527063},
doi = {10.1021/jacs.6b06821},
issn = {1520-5126 (Electronic)
0002-7863 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {J Am Chem Soc},
volume = {138},
number = {35},
pages = {11124-7},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
LaFave, L M; Beguelin, W; Koche, R; Teater, M; Spitzer, B; Chramiec, A; Papalexi, E; Keller, M D; Hricik, T; Konstantinoff, K; Micol, J B; Durham, B; Knutson, S K; Campbell, J E; Blum, G; Shi, X; Doud, E H; Krivtsov, A V; Chung, Y R; Khodos, I; de Stanchina, E; Ouerfelli, O; Adusumilli, P S; Thomas, P M; Kelleher, N L; Luo, M; Keilhack, H; Abdel-Wahab, O; Melnick, A; Armstrong, S A; Levine, R L Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status" Journal Article Nat Med, 22 (6), pp. 578-9, 2016, ISSN: 1546-170X (Electronic)
1078-8956 (Linking). Links | BibTeX | Tags: @article{RN481,
title = {Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status"},
author = { L. M. LaFave and W. Beguelin and R. Koche and M. Teater and B. Spitzer and A. Chramiec and E. Papalexi and M. D. Keller and T. Hricik and K. Konstantinoff and J. B. Micol and B. Durham and S. K. Knutson and J. E. Campbell and G. Blum and X. Shi and E. H. Doud and A. V. Krivtsov and Y. R. Chung and I. Khodos and E. de Stanchina and O. Ouerfelli and P. S. Adusumilli and P. M. Thomas and N. L. Kelleher and M. Luo and H. Keilhack and O. Abdel-Wahab and A. Melnick and S. A. Armstrong and R. L. Levine},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27270773},
doi = {10.1038/nm.4094},
issn = {1546-170X (Electronic)
1078-8956 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Nat Med},
volume = {22},
number = {6},
pages = {578-9},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Liu, F; Koval, M; Ranganathan, S; Fanayan, S; Hancock, W S; Lundberg, E K; Beavis, R C; Lane, L; Duek, P; McQuade, L; Kelleher, N L; Baker, M S Systems Proteomics View of the Endogenous Human Claudin Protein Family Journal Article J Proteome Res, 15 (2), pp. 339-59, 2016, ISSN: 1535-3907 (Electronic)
1535-3893 (Linking). Links | BibTeX | Tags: @article{RN495,
title = {Systems Proteomics View of the Endogenous Human Claudin Protein Family},
author = { F. Liu and M. Koval and S. Ranganathan and S. Fanayan and W. S. Hancock and E. K. Lundberg and R. C. Beavis and L. Lane and P. Duek and L. McQuade and N. L. Kelleher and M. S. Baker},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26680015},
doi = {10.1021/acs.jproteome.5b00769},
issn = {1535-3907 (Electronic)
1535-3893 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {J Proteome Res},
volume = {15},
number = {2},
pages = {339-59},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
McClure, R A; Goering, A W; Ju, K S; Baccile, J A; Schroeder, F C; Metcalf, W W; Thomson, R J; Kelleher, N L Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations Journal Article ACS Chem Biol, 11 (12), pp. 3452-3460, 2016, ISSN: 1554-8937 (Electronic)
1554-8929 (Linking). Links | BibTeX | Tags: @article{RN472,
title = {Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations},
author = { R. A. McClure and A. W. Goering and K. S. Ju and J. A. Baccile and F. C. Schroeder and W. W. Metcalf and R. J. Thomson and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27809474},
doi = {10.1021/acschembio.6b00779},
issn = {1554-8937 (Electronic)
1554-8929 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {ACS Chem Biol},
volume = {11},
number = {12},
pages = {3452-3460},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Melani, R D; Seckler, H S; Skinner, O S; Vale, Do L H; Catherman, A D; Havugimana, P C; de Sousa, Valle M; Domont, G B; Kelleher, N L; Compton, P D CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis Journal Article J Vis Exp, (108), pp. 53597, 2016, ISSN: 1940-087X (Electronic)
1940-087X (Linking). Links | BibTeX | Tags: @article{RN485,
title = {CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis},
author = { R. D. Melani and H. S. Seckler and O. S. Skinner and L. H. Do Vale and A. D. Catherman and P. C. Havugimana and M. Valle de Sousa and G. B. Domont and N. L. Kelleher and P. D. Compton},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26967310},
doi = {10.3791/53597},
issn = {1940-087X (Electronic)
1940-087X (Linking)},
year = {2016},
date = {2016-01-01},
journal = {J Vis Exp},
number = {108},
pages = {53597},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Melani, R D; Skinner, O S; Fornelli, L; Domont, G B; Compton, P D; Kelleher, N L Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics Journal Article Mol Cell Proteomics, 15 (7), pp. 2423-34, 2016, ISSN: 1535-9484 (Electronic)
1535-9476 (Linking). Links | BibTeX | Tags: @article{RN482,
title = {Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics},
author = { R. D. Melani and O. S. Skinner and L. Fornelli and G. B. Domont and P. D. Compton and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27178327},
doi = {10.1074/mcp.M115.056523},
issn = {1535-9484 (Electronic)
1535-9476 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Mol Cell Proteomics},
volume = {15},
number = {7},
pages = {2423-34},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Moussazadeh, N; Berman, S H; Laufer, I; Gounder, M; Zheng, Y; Sommer, J; Bilsky, M H; Kelleher, N L; Brennan, C 365 Epigenetic Profiling Reveals a Unique Histone Code in Chordoma Journal Article Neurosurgery, 63 Suppl 1 , pp. 208, 2016, ISSN: 1524-4040 (Electronic)
0148-396X (Linking). Links | BibTeX | Tags: @article{RN476,
title = {365 Epigenetic Profiling Reveals a Unique Histone Code in Chordoma},
author = { N. Moussazadeh and S. H. Berman and I. Laufer and M. Gounder and Y. Zheng and J. Sommer and M. H. Bilsky and N. L. Kelleher and C. Brennan},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27399562},
doi = {10.1227/01.neu.0000489853.78064.b2},
issn = {1524-4040 (Electronic)
0148-396X (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Neurosurgery},
volume = {63 Suppl 1},
pages = {208},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Ntai, I; LeDuc, R D; Fellers, R T; Erdmann-Gilmore, P; Davies, S R; Rumsey, J; Early, B P; Thomas, P M; Li, S; Compton, P D; Ellis, M J; Ruggles, K V; Fenyo, D; Boja, E S; Rodriguez, H; Townsend, R R; Kelleher, N L Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts Journal Article Mol Cell Proteomics, 15 (1), pp. 45-56, 2016, ISSN: 1535-9484 (Electronic)
1535-9476 (Linking). Links | BibTeX | Tags: @article{RN498,
title = {Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts},
author = { I. Ntai and R. D. LeDuc and R. T. Fellers and P. Erdmann-Gilmore and S. R. Davies and J. Rumsey and B. P. Early and P. M. Thomas and S. Li and P. D. Compton and M. J. Ellis and K. V. Ruggles and D. Fenyo and E. S. Boja and H. Rodriguez and R. R. Townsend and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26503891},
doi = {10.1074/mcp.M114.047480},
issn = {1535-9484 (Electronic)
1535-9476 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Mol Cell Proteomics},
volume = {15},
number = {1},
pages = {45-56},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Ntai, I; Toby, T K; LeDuc, R D; Kelleher, N L A Method for Label-Free, Differential Top-Down Proteomics Journal Article Methods Mol Biol, 1410 , pp. 121-33, 2016, ISSN: 1940-6029 (Electronic)
1064-3745 (Linking). Links | BibTeX | Tags: @article{RN488,
title = {A Method for Label-Free, Differential Top-Down Proteomics},
author = { I. Ntai and T. K. Toby and R. D. LeDuc and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26867742},
doi = {10.1007/978-1-4939-3524-6_8},
issn = {1940-6029 (Electronic)
1064-3745 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Methods Mol Biol},
volume = {1410},
pages = {121-33},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Ong, T H; Romanova, E V; Roberts-Galbraith, R H; Yang, N; Zimmerman, T A; Collins, 3rd J J; Lee, J E; Kelleher, N L; Newmark, P A; Sweedler, J V Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea Journal Article J Biol Chem, 291 (15), pp. 8109-20, 2016, ISSN: 1083-351X (Electronic)
0021-9258 (Linking). Links | BibTeX | Tags: @article{RN487,
title = {Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea},
author = { T. H. Ong and E. V. Romanova and R. H. Roberts-Galbraith and N. Yang and T. A. Zimmerman and J. J. 3rd Collins and J. E. Lee and N. L. Kelleher and P. A. Newmark and J. V. Sweedler},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26884331},
doi = {10.1074/jbc.M115.709196},
issn = {1083-351X (Electronic)
0021-9258 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {J Biol Chem},
volume = {291},
number = {15},
pages = {8109-20},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Savaryn, J P; Skinner, O S; Fornelli, L; Fellers, R T; Compton, P D; Terhune, S S; Abecassis, M M; Kelleher, N L Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry Journal Article J Proteomics, 134 , pp. 76-84, 2016, ISSN: 1876-7737 (Electronic)
1874-3919 (Linking). Links | BibTeX | Tags: @article{RN505,
title = {Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry},
author = { J. P. Savaryn and O. S. Skinner and L. Fornelli and R. T. Fellers and P. D. Compton and S. S. Terhune and M. M. Abecassis and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25952688},
doi = {10.1016/j.jprot.2015.04.025},
issn = {1876-7737 (Electronic)
1874-3919 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {J Proteomics},
volume = {134},
pages = {76-84},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Savaryn, J P; Toby, T K; Catherman, A D; Fellers, R T; LeDuc, R D; Thomas, P M; Friedewald, J J; Salomon, D R; Abecassis, M M; Kelleher, N L Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection Journal Article Proteomics, 16 (14), pp. 2048-58, 2016, ISSN: 1615-9861 (Electronic)
1615-9853 (Linking). Links | BibTeX | Tags: @article{RN484,
title = {Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection},
author = { J. P. Savaryn and T. K. Toby and A. D. Catherman and R. T. Fellers and R. D. LeDuc and P. M. Thomas and J. J. Friedewald and D. R. Salomon and M. M. Abecassis and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27120713},
doi = {10.1002/pmic.201600008},
issn = {1615-9861 (Electronic)
1615-9853 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Proteomics},
volume = {16},
number = {14},
pages = {2048-58},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Savaryn, J P; Toby, T K; Kelleher, N L A researcher's guide to mass spectrometry-based proteomics Journal Article Proteomics, 16 (18), pp. 2435-43, 2016, ISSN: 1615-9861 (Electronic)
1615-9853 (Linking). Links | BibTeX | Tags: @article{RN473,
title = {A researcher's guide to mass spectrometry-based proteomics},
author = { J. P. Savaryn and T. K. Toby and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27553853},
doi = {10.1002/pmic.201600113},
issn = {1615-9861 (Electronic)
1615-9853 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Proteomics},
volume = {16},
number = {18},
pages = {2435-43},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Schroeter, E R; DeHart, C J; Schweitzer, M H; Thomas, P M; Kelleher, N L Bone protein "extractomics": comparing the efficiency of bone protein extractions of Gallus gallus in tandem mass spectrometry, with an eye towards paleoproteomics Journal Article PeerJ, 4 , pp. e2603, 2016, ISSN: 2167-8359 (Print). Links | BibTeX | Tags: @article{RN471,
title = {Bone protein "extractomics": comparing the efficiency of bone protein extractions of Gallus gallus in tandem mass spectrometry, with an eye towards paleoproteomics},
author = { E. R. Schroeter and C. J. DeHart and M. H. Schweitzer and P. M. Thomas and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27812413},
doi = {10.7717/peerj.2603},
issn = {2167-8359 (Print)},
year = {2016},
date = {2016-01-01},
journal = {PeerJ},
volume = {4},
pages = {e2603},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Skinner, O S; Havugimana, P C; Haverland, N A; Fornelli, L; Early, B P; Greer, J B; Fellers, R T; Durbin, K R; Vale, Do L H; Melani, R D; Seckler, H S; Nelp, M T; Belov, M E; Horning, S R; Makarov, A A; LeDuc, R D; Bandarian, V; Compton, P D; Kelleher, N L An informatic framework for decoding protein complexes by top-down mass spectrometry Journal Article Nat Methods, 13 (3), pp. 237-40, 2016, ISSN: 1548-7105 (Electronic)
1548-7091 (Linking). Links | BibTeX | Tags: @article{RN492,
title = {An informatic framework for decoding protein complexes by top-down mass spectrometry},
author = { O. S. Skinner and P. C. Havugimana and N. A. Haverland and L. Fornelli and B. P. Early and J. B. Greer and R. T. Fellers and K. R. Durbin and L. H. Do Vale and R. D. Melani and H. S. Seckler and M. T. Nelp and M. E. Belov and S. R. Horning and A. A. Makarov and R. D. LeDuc and V. Bandarian and P. D. Compton and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26780093},
doi = {10.1038/nmeth.3731},
issn = {1548-7105 (Electronic)
1548-7091 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Nat Methods},
volume = {13},
number = {3},
pages = {237-40},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Skinner, O S; Schachner, L F; Kelleher, N L The Search Engine for Multi-Proteoform Complexes: An Online Tool for the Identification and Stoichiometry Determination of Protein Complexes Journal Article Curr Protoc Bioinformatics, 56 , pp. 13 30 1-13 30 11, 2016, ISSN: 1934-340X (Electronic)
1934-3396 (Linking). Links | BibTeX | Tags: @article{RN470,
title = {The Search Engine for Multi-Proteoform Complexes: An Online Tool for the Identification and Stoichiometry Determination of Protein Complexes},
author = { O. S. Skinner and L. F. Schachner and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27930806},
doi = {10.1002/cpbi.16},
issn = {1934-340X (Electronic)
1934-3396 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Curr Protoc Bioinformatics},
volume = {56},
pages = {13 30 1-13 30 11},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Toby, T K; Fornelli, L; Kelleher, N L Progress in Top-Down Proteomics and the Analysis of Proteoforms Journal Article Annu Rev Anal Chem (Palo Alto Calif), 9 (1), pp. 499-519, 2016, ISSN: 1936-1335 (Electronic)
1936-1327 (Linking). Links | BibTeX | Tags: @article{RN480,
title = {Progress in Top-Down Proteomics and the Analysis of Proteoforms},
author = { T. K. Toby and L. Fornelli and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27306313},
doi = {10.1146/annurev-anchem-071015-041550},
issn = {1936-1335 (Electronic)
1936-1327 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Annu Rev Anal Chem (Palo Alto Calif)},
volume = {9},
number = {1},
pages = {499-519},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Zheng, Y; Fornelli, L; Compton, P D; Sharma, S; Canterbury, J; Mullen, C; Zabrouskov, V; Fellers, R T; Thomas, P M; Licht, J D; Senko, M W; Kelleher, N L Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression Journal Article Mol Cell Proteomics, 15 (3), pp. 776-90, 2016, ISSN: 1535-9484 (Electronic)
1535-9476 (Linking). Links | BibTeX | Tags: @article{RN502,
title = {Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression},
author = { Y. Zheng and L. Fornelli and P. D. Compton and S. Sharma and J. Canterbury and C. Mullen and V. Zabrouskov and R. T. Fellers and P. M. Thomas and J. D. Licht and M. W. Senko and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26272979},
doi = {10.1074/mcp.M115.053819},
issn = {1535-9484 (Electronic)
1535-9476 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Mol Cell Proteomics},
volume = {15},
number = {3},
pages = {776-90},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Zheng, Y; Huang, X; Kelleher, N L Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry Journal Article Curr Opin Chem Biol, 33 , pp. 142-50, 2016, ISSN: 1879-0402 (Electronic)
1367-5931 (Linking). Links | BibTeX | Tags: @article{RN478,
title = {Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry},
author = { Y. Zheng and X. Huang and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27371874},
doi = {10.1016/j.cbpa.2016.06.007},
issn = {1879-0402 (Electronic)
1367-5931 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Curr Opin Chem Biol},
volume = {33},
pages = {142-50},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
2015
|
Albright, J C; Henke, M T; Soukup, A A; McClure, R A; Thomson, R J; Keller, N P; Kelleher, N L Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation Journal Article ACS Chem Biol, 10 (6), pp. 1535-41, 2015, ISSN: 1554-8937 (Electronic)
1554-8929 (Linking). Links | BibTeX | Tags: @article{RN510,
title = {Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation},
author = { J. C. Albright and M. T. Henke and A. A. Soukup and R. A. McClure and R. J. Thomson and N. P. Keller and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25815712},
doi = {10.1021/acschembio.5b00025},
issn = {1554-8937 (Electronic)
1554-8929 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {ACS Chem Biol},
volume = {10},
number = {6},
pages = {1535-41},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Amiram, M; Haimovich, A D; Fan, C; Wang, Y S; Aerni, H R; Ntai, I; Moonan, D W; Ma, N J; Rovner, A J; Hong, S H; Kelleher, N L; Goodman, A L; Jewett, M C; Soll, D; Rinehart, J; Isaacs, F J Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids Journal Article Nat Biotechnol, 33 (12), pp. 1272-1279, 2015, ISSN: 1546-1696 (Electronic)
1087-0156 (Linking). Links | BibTeX | Tags: @article{RN497,
title = {Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids},
author = { M. Amiram and A. D. Haimovich and C. Fan and Y. S. Wang and H. R. Aerni and I. Ntai and D. W. Moonan and N. J. Ma and A. J. Rovner and S. H. Hong and N. L. Kelleher and A. L. Goodman and M. C. Jewett and D. Soll and J. Rinehart and F. J. Isaacs},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26571098},
doi = {10.1038/nbt.3372},
issn = {1546-1696 (Electronic)
1087-0156 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {Nat Biotechnol},
volume = {33},
number = {12},
pages = {1272-1279},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Bok, J W; Ye, R; Clevenger, K D; Mead, D; Wagner, M; Krerowicz, A; Albright, J C; Goering, A W; Thomas, P M; Kelleher, N L; Keller, N P; Wu, C C Fungal artificial chromosomes for mining of the fungal secondary metabolome Journal Article BMC Genomics, 16 , pp. 343, 2015, ISSN: 1471-2164 (Electronic)
1471-2164 (Linking). Links | BibTeX | Tags: @article{RN506,
title = {Fungal artificial chromosomes for mining of the fungal secondary metabolome},
author = { J. W. Bok and R. Ye and K. D. Clevenger and D. Mead and M. Wagner and A. Krerowicz and J. C. Albright and A. W. Goering and P. M. Thomas and N. L. Kelleher and N. P. Keller and C. C. Wu},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25925221},
doi = {10.1186/s12864-015-1561-x},
issn = {1471-2164 (Electronic)
1471-2164 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {BMC Genomics},
volume = {16},
pages = {343},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Cleland, T P; Schroeter, E R; Zamdborg, L; Zheng, W; Lee, J E; Tran, J C; Bern, M; Duncan, M B; Lebleu, V S; Ahlf, D R; Thomas, P M; Kalluri, R; Kelleher, N L; Schweitzer, M H Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis Journal Article J Proteome Res, 14 (12), pp. 5252-62, 2015, ISSN: 1535-3907 (Electronic)
1535-3893 (Linking). Links | BibTeX | Tags: @article{RN496,
title = {Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis},
author = { T. P. Cleland and E. R. Schroeter and L. Zamdborg and W. Zheng and J. E. Lee and J. C. Tran and M. Bern and M. B. Duncan and V. S. Lebleu and D. R. Ahlf and P. M. Thomas and R. Kalluri and N. L. Kelleher and M. H. Schweitzer},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26595531},
doi = {10.1021/acs.jproteome.5b00675},
issn = {1535-3907 (Electronic)
1535-3893 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {J Proteome Res},
volume = {14},
number = {12},
pages = {5252-62},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Compton, P D; Fornelli, L; Kelleher, N L; Skinner, O S Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry Journal Article Int J Mass Spectrom, 390 , pp. 132-136, 2015, ISSN: 1387-3806 (Print)
1387-3806 (Linking). Links | BibTeX | Tags: @article{RN494,
title = {Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry},
author = { P. D. Compton and L. Fornelli and N. L. Kelleher and O. S. Skinner},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26692813},
doi = {10.1016/j.ijms.2015.08.021},
issn = {1387-3806 (Print)
1387-3806 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {Int J Mass Spectrom},
volume = {390},
pages = {132-136},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Dam, D H; Lee, H; Lee, R C; Kim, K H; Kelleher, N L; Odom, T W Tunable loading of oligonucleotides with secondary structure on gold nanoparticles through a pH-driven method Journal Article Bioconjug Chem, 26 (2), pp. 279-85, 2015, ISSN: 1520-4812 (Electronic)
1043-1802 (Linking). Links | BibTeX | Tags: @article{RN516,
title = {Tunable loading of oligonucleotides with secondary structure on gold nanoparticles through a pH-driven method},
author = { D. H. Dam and H. Lee and R. C. Lee and K. H. Kim and N. L. Kelleher and T. W. Odom},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25564799},
doi = {10.1021/bc500562s},
issn = {1520-4812 (Electronic)
1043-1802 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {Bioconjug Chem},
volume = {26},
number = {2},
pages = {279-85},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Durbin, K R; Skinner, O S; Fellers, R T; Kelleher, N L Analyzing internal fragmentation of electrosprayed ubiquitin ions during beam-type collisional dissociation Journal Article J Am Soc Mass Spectrom, 26 (5), pp. 782-7, 2015, ISSN: 1879-1123 (Electronic)
1044-0305 (Linking). Links | BibTeX | Tags: @article{RN513,
title = {Analyzing internal fragmentation of electrosprayed ubiquitin ions during beam-type collisional dissociation},
author = { K. R. Durbin and O. S. Skinner and R. T. Fellers and N. L. Kelleher},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25716753},
doi = {10.1007/s13361-015-1078-1},
issn = {1879-1123 (Electronic)
1044-0305 (Linking)},
year = {2015},
date = {2015-01-01},
journal = {J Am Soc Mass Spectrom},
volume = {26},
number = {5},
pages = {782-7},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
