Publications

342 entries « 1 of 7 »

2020

Fornelli, L; Srzentić, K; Toby, T K; Doubleday, P F; Huguet, R; Mullen, C; Melani, R D; Dos Santos Seckler, H; DeHart, C J; Weisbrod, C R; Durbin, K R; Greer, J B; Early, B P; Fellers, R T; Zabrouskov, V; Thomas, P M; Compton, P D; Kelleher, N L

Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics Journal Article

Mol Cell Proteomics., 19 (2), pp. 405-420, 2020.

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Kafader, J O; Melani, R D; Schachner, L F; Ives, A N; Patrie, S M; Kelleher, N L; Compton, P D

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions Journal Article

J Am Soc Mass Spectrom., 2020.

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Navarro-Muñoz, J C; Selem-Mojica, N; Mullowney, M W; Kautsar, S A; Tryon, J H; Parkinson, E I; De Los Santos, E L C; Yeong, M; Cruz-Morales, P; Abubucker, S; Roeters, A; Lokhorst, W; Fernandez-Guerra, A; Cappelini, L T D; Goering, A W; Thomson, R J; Metcalf, W W; Kelleher, N L; Barona-Gomez, F; Medema, M H

A computational framework to explore large-scale biosynthetic diversity Journal Article

Nat Chem Biol., 16 (1), pp. 60-68, 2020.

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Park, H M; Winton, V J; Drader, J J; Manalili Wheeler, S; Lazar, G A; Kelleher, N L; Liu, Y; Tran, J C; Compton, P D

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry Journal Article

Anal Chem., 92 (2), pp. 2186-2193, 2020.

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Montaser, R; Kelleher, N L

Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites Journal Article

ACS Chem Biol. , 2020.

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Winer, B; Edgel, K A; Zou, X; Sellau, J; Hadiwidjojo, S; Garver, L S; McDonough, C E; Kelleher, N L; Thomas, P M; Villasante, E; Ploss, A; Gerbasi, V R

Identification of Plasmodium falciparum proteoforms from liver stage models Journal Article

Malar J., 19 (1), pp. 10, 2020.

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Doubleday, P F; Fornelli, L; Kelleher, N L

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype Journal Article

J Proteome Res., 2020.

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2019

Camarillo, J M; Swaminathan, S; Abshiru, N A; Sikora, J W; Thomas, P M; Kelleher, N L

Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes Journal Article

J Am Soc Mass Spectrom., 30 (12), pp. 2526-2534, 2019.

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Melani, R D; Srzentić, K; Gerbasi, V R; McGee, J P; Huguet, R; Fornelli, L; Kelleher, N L

Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry Journal Article

MAbs., 11 (8), pp. 1351-1357, 2019.

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Des Soye, B J; Gerbasi, V R; Thomas, P M; Kelleher, N L; Jewett, M C

A Highly Productive, One-Pot Cell-Free Protein Synthesis Platform Based on Genomically Recoded Escherichia coli Journal Article

Cell Chem Biol., 26 (12), pp. 1743-1754, 2019.

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Huguet, R; Mullen, C; Srzentić, K; Greer, J B; Fellers, R T; Zabrouskov, V; Syka, J E P; Kelleher, N L; Fornelli, L

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms Journal Article

Anal Chem., 91 (24), pp. 15732-15739, 2019.

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Kafader, J O; Beu, S C; Early, B P; Melani, R D; Durbin, K R; Zabrouskov, V; Makarov, A A; Maze, J T; Shinholt, D L; Yip, P F; Kelleher, N L; Compton, P D; Senko, M W

STORI Plots Enable Accurate Tracking of Individual Ion Signals Journal Article

J Am Soc Mass Spectrom., 30 (11), pp. 2200-2203, 2019.

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Park, H M; Satta, R; Davis, R G; Goo, Y A; LeDuc, R D; Fellers, R T; Greer, J B; Romanova, E V; Rubakhin, S S; Tai, R; Thomas, P M; Sweedler, J V; Kelleher, N L; Patrie, S M; Lasek, A W

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol Journal Article

J Proteome Res., 18 (11), pp. 3999-4012, 2019.

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Schneider, J R; Shen, X; Orlandi, C; Nyanhete, T; Sawant, S; Carias, A M; Smith, A D; Kelleher, N L; Veazey, R S; Lewis, G K; Tomaras, G D; Hope, T J

A MUC16 IgG binding activity selects for a restricted subset of IgG enriched for certain SIV epitope specificities Journal Article

J Virol., 2019.

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Bennett, R L; Bele, A; Small, E C; Will, C M; Nabet, B; Oyer, J A; Huang, X; Ghosh, R P; Grzybowski, A T; Yu, T; Zhang, Q; Riva, A; Lele, T P; Schatz, G C; Kelleher, N L; Ruthenburg, A J; Liphardt, J; Licht, J D

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver Journal Article

Cancer Discov., 9 (10), pp. 1438-1451, 2019.

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Smith, L M; Thomas, P M; Shortreed, M R; Schaffer, L V; Fellers, R T; LeDuc, R D; Tucholski, T; Ge, Y; Agar, J N; Anderson, L C; Chamot-Rooke, J; Gault, J; Loo, J A; Paša-Tolić, L; Robinson, C V; Schlüter, H; Tsybin, Y O; Vilaseca, M; Vizcaíno, J A; Danis, P O; Kelleher, N L

A five-level classification system for proteoform identifications Journal Article

Nat Methods., 16 (10), pp. 939-940, 2019.

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Lue, J K; Prabhu, S A; Liu, Y; Gonzalez, Y; Verma, A; Mundi, P S; Abshiru, N; Camarillo, J M; Mehta, S; Chen, E I; Qiao, C; Nandakumar, R; Cremers, S; Kelleher, N L; Elemento, O; Amengual, J E

Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas Journal Article

Clin Cancer Res, 25 (17), pp. 5271-5283, 2019.

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Huang, X; LeDuc, R D; Fornelli, L; Schunter, A J; Bennett, R L; Kelleher, N L; Licht, J D

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding Journal Article

J Biol Chem., 294 (33), pp. 12459-12471, 2019.

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Schachner, L F; Ives, A N; McGee, J P; Melani, R D; Kafader, J O; Compton, P D; Patrie, S M; Kelleher, N L

Standard Proteoforms and Their Complexes for Native Mass Spectrometry Journal Article

Journal of the American Society for Mass Spectrometry, 30 (7), pp. 1190-1198, 2019.

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Donnelly, D P; Rawlins, C M; DeHart, C J; Fornelli, L; Schachner, L F; Lin, Z; Lippens, J L; Aluri, K C; Sarin, R; Chen, B; Lantz, C; Jung, W; Johnson, K R; Koller, A; Wolff, J J; Campuzano, I D G; Auclair, J R; Ivanov, A R; Whitelegge, J P; Paša-Tolić, L; Chamot-Rooke, J; Danis, P O; Smith, L M; Tsybin, Y O; Loo, J A; Ge, Y; Kelleher, N L; Agar, J N

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry Journal Article

Nat Methods., 16 (7), pp. 587-594, 2019.

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Moschitto, M J; Doubleday, P F; Catlin, D S; Kelleher, N L; Liu, D; Silverman, R B

Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid Journal Article

J Am Chem Soc., 14 (27), pp. 10711-10721, 2019.

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Ro, S Y; Schachner, L F; Koo, C W; Purohit, R; Remis, J P; Kenney, G E; Liauw, B W; Thomas, P M; Patrie, S M; Kelleher, N L; Rosenzweig, A C

Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase Journal Article

Nat Commun., 10 (1), pp. 2675, 2019.

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Schaffer, L V; Millikin, R J; Miller, R M; Anderson, L C; Fellers, R T; Ge, Y; Kelleher, N L; LeDuc, R D; Liu, X; Payne, S H; Sun, L; Thomas, P M; Tucholski, T; Wang, Z; Wu, S; Wu, Z; Yu, D; Shortreed, M R; Smith, L M

Identification and Quantification of Proteoforms by Mass Spectrometry Journal Article

Proteomics and Systems Biology, 19 (10), 2019.

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LeDuc, R D; Fellers, R T; Early, B P; Greer, J B; Shams, D P; Thomas, P; Kelleher, N L

Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics Journal Article

Mol Cell Proteomics., 18 (4), pp. 796-805, 2019.

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Cline, E N; Das, A; Bicca, M A; Mohammad, S N; Schachner, L F; Kamel, J M; DiNunno, N; Weng, A; Paschall, J D; Bu, R L; Khan, F M; Rollins, M G; Ives, A N; Shekhawat, G; Nunes-Tavares, N; de Mello, F G; Compton, P D; Kelleher, N L; Klein, W L

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies Journal Article

J Neurochem., 148 (6), pp. 822-836, 2019.

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Kafader, J O; Melani, R D; Senko, M W; Makarov, A A; Kelleher, N L; Compton, P D

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins Journal Article

Anal Chem., 91 (4), pp. 2776-2783, 2019.

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Swaroop, A; Oyer, J A; Will, C M; Huang, X; Yu, W; Troche, C; Bulic, M; Durham, B H; Wen, Q J; Crispino, J D; MacKerell, Jr A D; Bennett, R L; Kelleher, N L; Licht, J D

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia Journal Article

Oncogene., 38 (5), pp. 671-686, 2019.

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Jin, Q; Martinez, C A; Arcipowski, K M; Zhu, Y; Gutierrez-Diaz, B T; Wang, K K; Johnson, M R; Volk, A G; Wang, F; Wu, J; Grove, C; Wang, H; Sokirniy, I; Thomas, P M; Goo, Y A; Abshiru, N A; Hijiya, N; Peirs, S; Vandamme, N; Berx, G; Goosens, S; Marshall, S A; Rendleman, E J; Takahashi, Y H; Wang, L; Rawat, R; Bartom, E T; Collings, C K; Van Vlierberghe, P; Strikoudis, A; Kelly, S; Ueberheide, B; Mantis, C; Kandela, I; Bourquin, J P; Bornhauser, B; Serafin, V; Bresolin, S; Paganin, M; Accordi, B; Basso, G; Kelleher, N L; Weinstock, J; Kumar, S; Crispino, J D; Shilatifard, A; Ntziachristos, P

USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia Journal Article

Clin Cancer Res., 25 (1), pp. 222-239, 2019.

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Toby, T K; Fornelli, L; Srzentić, K; DeHart, C J; Levitsky, J; Friedewald, J; Kelleher, N L

A comprehensive pipeline for translational top-down proteomics from a single blood draw Journal Article

Nat Protoc., 14 (1), pp. 119-152, 2019.

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2018

Alvares, K; DeHart, C J; Thomas, P M; Kelleher, N L; Veis, A

The unique biomineralization transcriptome and proteome of Lytechinus variegatus teeth Journal Article

Connect Tissue Res., 59 (sup1), pp. 20-29, 2018.

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Fisher, O S; Kenney, G E; Ross, M O; Ro, S Y; Lemma, B E; Batelu, S; Thomas, P M; Sosnowski, V C; DeHart, C J; Kelleher, N L; Stemmler, T L; Hoffman, B M; Rosenzweig, A C

Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria Journal Article

Nat Commun., 9 (1), pp. 4276, 2018.

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Mullowney, M W; McClure, R A; Robey, M T; Kelleher, N L; Thomson, R J

Natural products from thioester reductase containing biosynthetic pathways Journal Article

Nat Prod Rep., 35 (9), pp. 847-878, 2018.

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Gruppuso, P A; Boylan, J M; Zabala, V; Neretti, N; Abshiru, N A; Sikora, J W; Doud, E H; Camarillo, J M; Thomas, P M; Kelleher, N L; Sanders, J A

Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells Journal Article

PLoS One., 13 (9), 2018.

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Compton, P D; Kelleher, N L; Gunawardena, J

Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry Journal Article

J Proteome Res., 17 (8), pp. 2727-2734, 2018.

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Fornelli, L; Srzentić, K; Huguet, R; Mullen, C; Sharma, S; Zabrouskov, V; Fellers, R T; Durbin, K R; Compton, P D; Kelleher, N L

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques Journal Article

Anal Chem., 90 (14), pp. 8421-8429, 2018.

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Riley, N M; Sikora, J W; Seckler, H S; Greer, J B; Fellers, R T; LeDuc, R D; Westphall, M S; Thomas, P M; Kelleher, N L; Coon, J J

The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins Journal Article

Anal Chem., 90 (14), pp. 8553-8560, 2018.

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Park, Y J; Kenney, G E; Schachner, L F; Kelleher, N L; Rosenzweig, A C

Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins Journal Article

Biochemistry, 57 (25), pp. 3515-3523, 2018.

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Clevenger, K D; Ye, R; Bok, J W; Thomas, P M; Islam, M N; Miley, G P; Robey, M T; Chen, C; Yang, K; Swyers, M; Wu, E; Gao, P; Wu, C C; Keller, N P; Kelleher, N L

Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity. Journal Article

Biochemistry, 57 (23), pp. 3237-3243, 2018.

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Seckler, H D S; Fornelli, L; Mutharasan, R K; Thaxton, C S; Fellers, R; Daviglus, M; Sniderman, A; Rader, D; Kelleher, N L; Lloyd-Jones, D M; Compton, P D; Wilkins, J T

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity. Journal Article

J Proteome Res., 17 (6), pp. 2156-2164, 2018.

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Robey, M T; Ye, R; Bok, J W; Clevenger, K D; Islam, M N; Chen, C; Gupta, R; Swyers, M; Wu, E; Gao, P; Thomas, P M; Wu, C C; Keller, N P; Kelleher, N L

Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology. Journal Article

ACS Chem Biol., 13 (5), pp. 1142-1147, 2018.

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Zheng, J; Chen, L; Skinner, O S; Ysselstein, D; Remis, J; Lansbury, P; Skerlj, R; Mrosek, M; Heunisch, U; Krapp, S; Charrow, J; Schwake, M; Kelleher, N L; Silverman, R B; Krainc, D

β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site Journal Article

J Am Chem Soc., 140 (18), pp. 5914-5924, 2018.

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Parkinson, E I; Tryon, J H; Goering, A W; Ju, K S; McClure, R A; Kemball, J D; Zhukovsky, S; Labeda, D P; Thomson, R J; Kelleher, N L; Metcalf, W W

Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics. Journal Article

ACS Chem Biol., 13 (4), pp. 1029-1037, 2018.

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Miley, G P; Rote, J C; Silverman, R B; Kelleher, N L; Thomson, R J

Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization. Journal Article

Org Lett., 20 (8), pp. 2369-2373, 2018.

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Ntai, I; Fornelli, L; DeHart, C J; Hutton, J E; Doubleday, P F; LeDuc, R D; van Nispen, A J; Fellers, R T; Whiteley, G; Boja, E S; Rodriguez, H; Kelleher, N L

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk. Journal Article

Proc Natl Acad Sci USA, 115 (16), pp. 4140-4145, 2018.

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Kenney, G E; Dassama, L M K; Pandelia, M E; Gizzi, A S; Martinie, R J; Gao, P; DeHart, C J; Schachner, L F; Skinner, O S; Ro, S Y; Zhu, X; Sadek, M; Thomas, P M; Almo, S C; Bollinger, J M; Jr Krebs, C; Kelleher, N L; Rosenzweig, AC

The biosynthesis of methanobactin. Journal Article

Science, 359 (6382), pp. 1411-1416, 2018.

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Martin, R W; Des Soye, B J; Kwon, Y C; Kay, J; Davis, R G; Thomas, P M; Majewska, N I; Chen, C X; Marcum, R D; Weiss, M G; Stoddart, A E; Amiram, M; Ranji Charna, A K; Patel, J R; Isaacs, F J; Kelleher, N L; Hong, S H; Jewett, MC

Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids. Journal Article

Nat. Commun., 9 (1), pp. 1203, 2018.

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Davis, R G; Park, H M; Kim, K; Greer, J B; Fellers, R T; LeDuc, R D; Romanova, E V; Rubakhin, S S; Zombeck, J A; Wu, C; Yau, P M; Gao, P; van Nispen, A J; Patrie, S M; Thomas, P M; Sweedler, J V; Rhodes, J S; Kelleher, N L

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains. Journal Article

Anal Chem, 90 (6), pp. 3802-3810, 2018.

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Smith, L M; Kelleher, N L

Proteoforms as the next proteomics currency. Journal Article

Science, 359 (6380), pp. 1106-1107, 2018.

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LeDuc, R; Schwammle, V; Shortreed, MR ; Cesnick, AJ ; Solntsev, SK ; Shaw, JB ; Martin, MJ ; Vizcaino, JA ; Alpi, E; Danis, P; Kelleher, NL ; Smith, LM ; Ge, Y; Agar, JN ; Chamot-Rooke, J; Loo, JA ; Pasa-Tolic, L; Tsybin, YO

ProForma: A Standard Proteoform Notation. Journal Article

J Proteome Res., 17 (3), pp. 1321-1325, 2018.

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Aebersold, R; Agar, JN ; Amster, IJ ; Baker, MS ; Bertozzi, CR ; Boja, ES ; Costello, CE ; Cravatt, BF ; Fenselau, C; Garcia, BA ; Ge, Y; Gunawardena, J; Hendrickson, RC ; Hergenrother, PJ ; Huber, CG ; Ivanov, AR ; Jensen, ON ; Jewett, MC ; Kelleher, NL ; Kiessling, LL ; Krogan, NJ ; Larsen, MR ; Loo, JA ; Ogorzalek, Loo RR ; Lundberg, E; MacCoss, MJ ; Mallick, P; Mootha, VK ; Mrksich, M; Muir, TW ; Patrie, SM ; Pesavento, JJ ; Pitteri, SJ ; Rodriguez, H; Saghatelian, A; Sandoval, W; Schlüter, H; Sechi, S; Slavoff, SA ; Smith, LM ; Snyder, MP ; Thomas, PM ; Uhlén, M; Van Eyk, JE ; Vidal, M; Walt, DR ; White, FM ; Williams, ER ; Wohlschlager, T; Wysocki, VH ; Yates, NA ; Young, NL ; Zhang, B

How many human proteoforms are there? Journal Article

Nat Chem Biol., 14 (3), pp. 206-214, 2018.

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342 entries « 1 of 7 »