Publications

365 entries « 1 of 8 »

2021

McGee, J P; Melani, R D; Yip, P F; Senko, M W; Compton, P D; Kafader, J O; Kelleher, N L

Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry Journal Article

Anal Chem., 93 (5), pp. 2723-2727, 2021.

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Liu, Y; Davis, R G; Thomas, P M; Kelleher, N L; Jewett, M C

In vitro-Constructed Ribosomes Enable Multi-site Incorporation of Noncanonical Amino Acids into Proteins Journal Article

Biochemistry., 60 (3), pp. 161-169, 2021.

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Yusufova, N; Kloetgen, A; Teater, M; Osunsade, A; Camarillo, J M; Chin, C R; Doane, A S; Venters, B J; Portillo-Ledesma, S; Conway, J; Phillip, J M; Elemento, O; Scott, D W; Béguelin, W; Licht, J D; Kelleher, N L; Staudt, L M; Skoultchi, A I; Keogh, M C; Apostolou, E; Mason, C E; Imielinski, M; Schlick, T; David, Y; Tsirigos, A; Allis, C D; Soshnev, A A; Cesarman, E; Melnick, A M

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture Journal Article

Nature., 589 (7841), pp. 299-305, 2021.

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2020

Hoofnagle, A N; Cobbaert, C M; Delatour, V; Kelleher, N L; Lowenthal, M S; Shuford, C M

Should LC-MS/MS Be the Reference Measurement Procedure to Determine Protein Concentrations in Human Samples? Journal Article

Clin Chem., 2020.

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Hamm, P S; Dunlap, C A; Mullowney, M W; Caimi, N A; Kelleher, N L; Thomson, R J; Porras-Alfaro, A; Northup, D E

Streptomyces buecherae sp. nov., an actinomycete isolated from multiple bat species Journal Article

Antonie Van Leeuwenhoek., 113 (12), pp. 2213-2221, 2020.

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An, S; Camarillo, J M; Huang, T Y; Li, D; Morris, J A; Zoltek, M A; Qi, J; Behbahani, M; Kambhampati, M; Kelleher, N L; Nazarian, J; Thomas, P M; Saratsis, A M

Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma Journal Article

J Exp Clin Cancer Res., 39 (1), pp. 261, 2020.

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Tryon, J H; Rote, J C; Chen, L; Robey, M T; Vega, M M; Phua, W C; Metcalf, W W; Ju, K S; Kelleher, N L; Thomson, R J

Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster Journal Article

ACS Chem Biol. , 15 (11), pp. 3013-3020, 2020.

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Caesar, L K; Kelleher, N L; Keller, N P

In the fungus where it happens: History and future propelling Aspergillus nidulans as the archetype of natural products research Journal Article

Fungal Genet Biol., 144 , 2020.

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Abshiru, N A; Sikora, J W; Camarillo, J M; Morris, J A; Compton, P D; Lee, T; Neelamraju, Y; Haddox, S; Sheridan, C; Carroll, M; Cripe, L D; Tallman, M S; Paietta, E M; Melnick, A M; Thomas, P M; Garrett-Bakelman, F E; Kelleher, N L

Targeted detection and quantitation of histone modifications from 1,000 cells Journal Article

PLoS One., 15 (10), 2020.

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Deighan, W I; Winton, V J; Melani, R D; Anderson, L C; McGee, J P; Schachner, L F; Barnidge, D; Murray, D; Alexander, H D; Gibson, D S; Deery, M J; McNicholl, F P; McLaughlin, J; Kelleher, N L; Thomas, P M

Development of novel methods for non-canonical myeloma protein analysis with an innovative adaptation of immunofixation electrophoresis, native top-down mass spectrometry, and middle-down de novo sequencing Journal Article

Clin Chem Lab Med., 2020.

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Srzentić, K; Fornelli, L; Tsybin, Y O; Loo, J A; Seckler, H; Agar, J N; Anderson, L C; Bai, D L; Beck, A; Brodbelt, J S; van der Burgt, Y E M; Chamot-Rooke, J; Chatterjee, S; Chen, Y; Clarke, D J; Danis, P O; Diedrich, J K; D'Ippolito, R A; Dupré, M; Gasilova, N; Ge, Y; Goo, Y A; Goodlett, D R; Greer, S; Haselmann, K F; He, L; Hendrickson, C L; Hinkle, J D; Holt, M V; Hughes, S; Hunt, D F; Kelleher, N L; Kozhinov, A N; Lin, Z; Malosse, C; Marshall, A G; Menin, L; Millikin, R J; Nagornov, K O; Nicolardi, S; Paša-Tolić, L; Pengelley, S; Quebbemann, N R; Resemann, A; Sandoval, W; Sarin, R; Schmitt, N D; Shabanowitz, J; Shaw, J B; Shortreed, M R; Smith, L M; Sobott, F; Suckau, D; Toby, T; Weisbrod, C R; Wildburger, N C; Yates, 3rd J R; Yoon, S H; Young, N L; Zhou, M

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. Journal Article

J Am Soc Mass Spectrom., 31 (9), pp. 1783-1802, 2020.

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Caesar, L K; Robey, M T; Swyer, M; Islam, M N; Ye, R; Vagadia, P P; Schiltz, G E; Thomas, P M; Wu, C C; Kelleher, N L; Keller, N P; Bok, J W

Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds. Journal Article

mBio., 11 (4), 2020.

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Ives, A N; Su, T; Durbin, K R; Early, B P; Dos Santos Seckler, H; Fellers, R T; LeDuc, R D; Schachner, L F; Patrie, S M; Kelleher, N L

Using 10,000 Fragment Ions to Inform Scoring in Native Top-down Proteomics. Journal Article

J Am Soc Mass Spectrom., 31 (7), pp. 1398-1409, 2020.

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Béguelin, W; Teater, M; Meydan, C; Hoehn, K B; Phillip, J M; Soshnev, A A; Venturutti, L; Rivas, M A; Calvo-Fernández, M T; Gutierrez, J; Camarillo, J M; Takata, K; Tarte, K; Kelleher, N L; Steidl, C; Mason, C E; Elemento, O; Allis, C D; Kleinstein, S H; Melnick, A M

Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response. Journal Article

Cancer Cell, 37 (5), pp. 655-673, 2020.

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Kafader, J O; Melani, R D; Durbin, K R; Ikwuagwu, B; Early, B P; Fellers, R T; Beu, S C; Zabrouskov, V; Makarov, A A; Maze, J T; Shinholt, D L; Yip, P F; Tullman-Ercek, D; Senko, M W; Compton, P D; Kelleher, N L

Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes. Journal Article

Nat Methods., 17 (4), pp. 391-394, 2020.

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Zhu, W; Doubleday, P F; Catlin, D S; Weerawarna, P M; Butrin, A; Shen, S; Wawrzak, Z; Kelleher, N L; Liu, D; Silverman, R B

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. Journal Article

J Am Chem Soc., 142 (10), pp. 4892-4903, 2020.

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Kafader, J O; Durbin, K R; Melani, R D; Des Soye, B J; Schachner, L F; Senko, M W; Compton, P D; Kelleher, N L

Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry. Journal Article

J Proteome Res., 19 (3), pp. 1346-1350, 2020.

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McGee, J P; Melani, R D; Goodwin, M; McAlister, G; Huguet, R; Senko, M W; Compton, P D; Kelleher, N L

Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis. Journal Article

J Am Soc Mass Spectrom., 31 (3), pp. 763-767, 2020.

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Kosciuk, T; Price, I R; Zhang, X; Zhu, C; Johnson, K N; Zhang, S; Halaby, S L; Komaniecki, G P; Yang, M; DeHart, C J; Thomas, P M; Kelleher, N L; Fromme, J C; Lin, H

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Journal Article

Nat Commun., 11 (1), pp. 1067, 2020.

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Shen, S; Doubleday, P F; Weerawarna, P M; Zhu, W; Kelleher, N L; Silverman, R B

Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase Journal Article

ACS Med Chem Lett., 11 (10), pp. 1949-1955, 2020.

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Schneider, J R; Shen, X; Orlandi, C; Nyanhete, T; Sawant, S; Carias, A M; Smith, 4th A D; Kelleher, N L; Veazey, R S; Lewis, G K; Tomaras, G D; Hope, T J

A MUC16 IgG Binding Activity Selects for a Restricted Subset of IgG Enriched for Certain Simian Immunodeficiency Virus Epitope Specificities. Journal Article

J Virol., 94 (5), 2020.

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Fornelli, L; Srzentić, K; Toby, T K; Doubleday, P F; Huguet, R; Mullen, C; Melani, R D; Dos Santos Seckler, H; DeHart, C J; Weisbrod, C R; Durbin, K R; Greer, J B; Early, B P; Fellers, R T; Zabrouskov, V; Thomas, P M; Compton, P D; Kelleher, N L

Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics Journal Article

Mol Cell Proteomics., 19 (2), pp. 405-420, 2020.

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Kafader, J O; Melani, R D; Schachner, L F; Ives, A N; Patrie, S M; Kelleher, N L; Compton, P D

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions Journal Article

J Am Soc Mass Spectrom., 31 (3), pp. 574-581, 2020.

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Navarro-Muñoz, J C; Selem-Mojica, N; Mullowney, M W; Kautsar, S A; Tryon, J H; Parkinson, E I; De Los Santos, E L C; Yeong, M; Cruz-Morales, P; Abubucker, S; Roeters, A; Lokhorst, W; Fernandez-Guerra, A; Cappelini, L T D; Goering, A W; Thomson, R J; Metcalf, W W; Kelleher, N L; Barona-Gomez, F; Medema, M H

A computational framework to explore large-scale biosynthetic diversity Journal Article

Nat Chem Biol., 16 (1), pp. 60-68, 2020.

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Park, H M; Winton, V J; Drader, J J; Manalili Wheeler, S; Lazar, G A; Kelleher, N L; Liu, Y; Tran, J C; Compton, P D

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry Journal Article

Anal Chem., 92 (2), pp. 2186-2193, 2020.

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Montaser, R; Kelleher, N L

Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites Journal Article

ACS Chem Biol. , 2020.

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Winer, B; Edgel, K A; Zou, X; Sellau, J; Hadiwidjojo, S; Garver, L S; McDonough, C E; Kelleher, N L; Thomas, P M; Villasante, E; Ploss, A; Gerbasi, V R

Identification of Plasmodium falciparum proteoforms from liver stage models Journal Article

Malar J., 19 (1), pp. 10, 2020.

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Doubleday, P F; Fornelli, L; Kelleher, N L

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype Journal Article

J Proteome Res., 2020.

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Navarro-Muñoz, J C; Selem-Mojica, N; Mullowney, M W; Kautsar, S A; Tryon, J H; Parkinson, E I; De Los Santos, E L C; Yeong, M; Cruz-Morales, P; Abubucker, S; Roeters, A; Lokhorst, W; Fernandez-Guerra, A; Cappelini, L T D; Goering, A W; Thomson, R J; Metcalf, W W; Kelleher, N L; Barona-Gomez, F; Medema, M H

A computational framework to explore large-scale biosynthetic diversity Journal Article

Nat Chem Biol., 16 (10), pp. 60-68, 2020.

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2019

Camarillo, J M; Swaminathan, S; Abshiru, N A; Sikora, J W; Thomas, P M; Kelleher, N L

Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes Journal Article

J Am Soc Mass Spectrom., 30 (12), pp. 2526-2534, 2019.

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Melani, R D; Srzentić, K; Gerbasi, V R; McGee, J P; Huguet, R; Fornelli, L; Kelleher, N L

Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry Journal Article

MAbs., 11 (8), pp. 1351-1357, 2019.

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Des Soye, B J; Gerbasi, V R; Thomas, P M; Kelleher, N L; Jewett, M C

A Highly Productive, One-Pot Cell-Free Protein Synthesis Platform Based on Genomically Recoded Escherichia coli Journal Article

Cell Chem Biol., 26 (12), pp. 1743-1754, 2019.

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Huguet, R; Mullen, C; Srzentić, K; Greer, J B; Fellers, R T; Zabrouskov, V; Syka, J E P; Kelleher, N L; Fornelli, L

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms Journal Article

Anal Chem., 91 (24), pp. 15732-15739, 2019.

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Ling, T; Birger, Y; Stankiewicz, M J; Ben-Haim, N; Kalisky, T; Rein, A; Kugler, E; Chen, W; Fu, C; Zhang, K; Patel, H; Sikora, J W; Goo, Y A; Kelleher, N; Zou, L; Izraeli, S; Crispino, J D

Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis Journal Article

Blood, 134 (19), pp. 1619 - 1631, 2019.

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Kafader, J O; Beu, S C; Early, B P; Melani, R D; Durbin, K R; Zabrouskov, V; Makarov, A A; Maze, J T; Shinholt, D L; Yip, P F; Kelleher, N L; Compton, P D; Senko, M W

STORI Plots Enable Accurate Tracking of Individual Ion Signals Journal Article

J Am Soc Mass Spectrom., 30 (11), pp. 2200-2203, 2019.

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Park, H M; Satta, R; Davis, R G; Goo, Y A; LeDuc, R D; Fellers, R T; Greer, J B; Romanova, E V; Rubakhin, S S; Tai, R; Thomas, P M; Sweedler, J V; Kelleher, N L; Patrie, S M; Lasek, A W

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol Journal Article

J Proteome Res., 18 (11), pp. 3999-4012, 2019.

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Schneider, J R; Shen, X; Orlandi, C; Nyanhete, T; Sawant, S; Carias, A M; Smith, A D; Kelleher, N L; Veazey, R S; Lewis, G K; Tomaras, G D; Hope, T J

A MUC16 IgG binding activity selects for a restricted subset of IgG enriched for certain SIV epitope specificities Journal Article

J Virol., 2019.

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Bennett, R L; Bele, A; Small, E C; Will, C M; Nabet, B; Oyer, J A; Huang, X; Ghosh, R P; Grzybowski, A T; Yu, T; Zhang, Q; Riva, A; Lele, T P; Schatz, G C; Kelleher, N L; Ruthenburg, A J; Liphardt, J; Licht, J D

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver Journal Article

Cancer Discov., 9 (10), pp. 1438-1451, 2019.

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Smith, L M; Thomas, P M; Shortreed, M R; Schaffer, L V; Fellers, R T; LeDuc, R D; Tucholski, T; Ge, Y; Agar, J N; Anderson, L C; Chamot-Rooke, J; Gault, J; Loo, J A; Paša-Tolić, L; Robinson, C V; Schlüter, H; Tsybin, Y O; Vilaseca, M; Vizcaíno, J A; Danis, P O; Kelleher, N L

A five-level classification system for proteoform identifications Journal Article

Nat Methods., 16 (10), pp. 939-940, 2019.

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Lue, J K; Prabhu, S A; Liu, Y; Gonzalez, Y; Verma, A; Mundi, P S; Abshiru, N; Camarillo, J M; Mehta, S; Chen, E I; Qiao, C; Nandakumar, R; Cremers, S; Kelleher, N L; Elemento, O; Amengual, J E

Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas Journal Article

Clin Cancer Res, 25 (17), pp. 5271-5283, 2019.

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Huang, X; LeDuc, R D; Fornelli, L; Schunter, A J; Bennett, R L; Kelleher, N L; Licht, J D

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding Journal Article

J Biol Chem., 294 (33), pp. 12459-12471, 2019.

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Schachner, L F; Ives, A N; McGee, J P; Melani, R D; Kafader, J O; Compton, P D; Patrie, S M; Kelleher, N L

Standard Proteoforms and Their Complexes for Native Mass Spectrometry Journal Article

Journal of the American Society for Mass Spectrometry, 30 (7), pp. 1190-1198, 2019.

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Donnelly, D P; Rawlins, C M; DeHart, C J; Fornelli, L; Schachner, L F; Lin, Z; Lippens, J L; Aluri, K C; Sarin, R; Chen, B; Lantz, C; Jung, W; Johnson, K R; Koller, A; Wolff, J J; Campuzano, I D G; Auclair, J R; Ivanov, A R; Whitelegge, J P; Paša-Tolić, L; Chamot-Rooke, J; Danis, P O; Smith, L M; Tsybin, Y O; Loo, J A; Ge, Y; Kelleher, N L; Agar, J N

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry Journal Article

Nat Methods., 16 (7), pp. 587-594, 2019.

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Moschitto, M J; Doubleday, P F; Catlin, D S; Kelleher, N L; Liu, D; Silverman, R B

Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid Journal Article

J Am Chem Soc., 14 (27), pp. 10711-10721, 2019.

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Ro, S Y; Schachner, L F; Koo, C W; Purohit, R; Remis, J P; Kenney, G E; Liauw, B W; Thomas, P M; Patrie, S M; Kelleher, N L; Rosenzweig, A C

Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase Journal Article

Nat Commun., 10 (1), pp. 2675, 2019.

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Schaffer, L V; Millikin, R J; Miller, R M; Anderson, L C; Fellers, R T; Ge, Y; Kelleher, N L; LeDuc, R D; Liu, X; Payne, S H; Sun, L; Thomas, P M; Tucholski, T; Wang, Z; Wu, S; Wu, Z; Yu, D; Shortreed, M R; Smith, L M

Identification and Quantification of Proteoforms by Mass Spectrometry Journal Article

Proteomics and Systems Biology, 19 (10), 2019.

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LeDuc, R D; Fellers, R T; Early, B P; Greer, J B; Shams, D P; Thomas, P; Kelleher, N L

Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics Journal Article

Mol Cell Proteomics., 18 (4), pp. 796-805, 2019.

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Cline, E N; Das, A; Bicca, M A; Mohammad, S N; Schachner, L F; Kamel, J M; DiNunno, N; Weng, A; Paschall, J D; Bu, R L; Khan, F M; Rollins, M G; Ives, A N; Shekhawat, G; Nunes-Tavares, N; de Mello, F G; Compton, P D; Kelleher, N L; Klein, W L

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies Journal Article

J Neurochem., 148 (6), pp. 822-836, 2019.

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Kafader, J O; Melani, R D; Senko, M W; Makarov, A A; Kelleher, N L; Compton, P D

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins Journal Article

Anal Chem., 91 (4), pp. 2776-2783, 2019.

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Swaroop, A; Oyer, J A; Will, C M; Huang, X; Yu, W; Troche, C; Bulic, M; Durham, B H; Wen, Q J; Crispino, J D; MacKerell, Jr A D; Bennett, R L; Kelleher, N L; Licht, J D

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia Journal Article

Oncogene., 38 (5), pp. 671-686, 2019.

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365 entries « 1 of 8 »