ProSight PTM 2.0 allows identification and characterization of both intact proteins and peptides. Our ProSight Warehouses are annotated with all known post-translational modifications (PTMs), alternative splicing events and single nucleotide polymorphisms (SNPs) using the technique of Shotgun Annotation developed in the Kelleher Research Group. ProSightPTM is the only proteomics software that allows the user to search their tandem MS data against proteome warehouses containing the known biological complexity present in UniProt.

In 2015, Prof. Kelleher was awarded an NIH P41 grant, establishing the National Resource for Translational and Developmental Proteomics (NRTDP).  A major objective of the Resource is the dissemination of software to the scientific community.  This includes ProSightLite, a free Windows application for single protein characterization.